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Regulation of PD-L1(CD274) transcription

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9909649

PubChem

R-HSA-9909649

Description

The transcriptional regulation of CD274 (PD-L1/ programmed death-ligand 1) plays a critical role in the regulation of normal T cell function in normal physiological condition where it provides immune homeostasis. The expression of PD-L1 is tightly controlled by various transcription factors and signalling pathways, which respond to both intrinsic cellular signals and extrinsic environmental perturbations. PD-L1 is regulated transcriptionally by multiple mechanism like epigenetic modifications (EZH2, DNMTs, MLLs), transcription factors (STAT3. STAT1, IRF1, MYC, HIF and ither) which get activated in response to multiple upstream signalling pathways. The transcriptional regulation of PD-L1 is a complex interplay of oncogenic signalling pathways, cytokine responses, epigenetic modifications, specific transcription factors, the tumour microenvironment, and non-coding RNAs. This multifaceted regulation ensures that PD-L1 expression can be finely tuned to promote immunotolerance in normal condition as well as immune evasion in cancer, making it a critical target for cancer immunotherapy (Zhou et al.,2023, Cha et al.,2019, Yamaguchi et al.,2022, Ju et al.,2020)

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 51 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O60814	Histone H2B type 1-K	H2BC12 H2BFT HIRIP1 HIST1H2BK	view
O60885	Bromodomain-containing protein 4	BRD4 HUNK1	view
P01100	Protein c-Fos	FOS G0S7	view
P01106	Myc proto-oncogene protein	BHLHE39 MYC	view
P04198	N-myc proto-oncogene protein	BHLHE37 MYCN NMYC	view
P04908	Histone H2A type 1-B/E	H2AC4; H2AC8 H2AFA H2AFM HIST1H2AB HIST1H2AE	view
P05412	Transcription factor Jun	JUN	view
P06899	Histone H2B type 1-J	H2BC11 H2BFR HIST1H2BJ	view
P16104	Histone H2AX	H2AFX H2AX	view
P17535	Transcription factor JunD	JUND	view

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