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Dengue virus modulates apoptosis

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9920951

PubChem

R-HSA-9920951

Description

Apoptosis of cells during Dengue virus infection facilitates virus proliferation and enhances hemorrhagic fever (DHF) and shock syndrome. Apoptosis was demonstrated in liver, brain, intestinal and lung tissues (Limonta et al., 2007). It is known that the C protein and the NS2B:NS3 complex enhance apoptosis by binding to host factors. On the other hand, early apoptosis of an infected cell is inhibited by NS1, through maintaining autophagy, to allow replication and assembly (Lu et al., 2020; reviewed in Amara & Mercer, 2015).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 10** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P29990	Genome polyprotein		view
P42345	Serine/threonine-protein kinase mTOR	FRAP FRAP1 FRAP2 MTOR RAFT1 RAPT1	view
Q13546	Receptor-interacting serine/threonine-protein kinase 1	RIP RIP1 RIPK1	view
Q6R327	Rapamycin-insensitive companion of mTOR	KIAA1999 RICTOR	view
Q7L7X3	Serine/threonine-protein kinase TAO1	KIAA1361 MAP3K16 MARKK TAOK1	view
Q8N122	Regulatory-associated protein of mTOR	KIAA1303 RAPTOR RPTOR	view
Q99570	Phosphoinositide 3-kinase regulatory subunit 4	PIK3R4 VPS15	view
Q9BPZ7	Target of rapamycin complex 2 subunit MAPKAP1	MAPKAP1 MIP1 SIN1	view
Q9H6L5	Reticulophagy regulator 1	FAM134B JK1 RETREG1	view
Q9UER7	Death domain-associated protein 6	BING2 DAP6 DAXX	view

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