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Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9931512

PubChem

R-HSA-9931512

Description

After phosphorylated BMAL1:CLOCK heterodimers bind E-box elements in the promoters of target genes, CLOCK acetylates BMAL1 (inferred from mouse homologs in Hirayama et al. 2007) and becomes hyperphosphorylated through an incompletely characterized mechanism (inferred from the mouse homolog in Yoshitane et al. 2009, Robles et al. 2017). The hyperphosphorylation appears to both increase transcriptional activation activity and increase proteolytic degradation of CLOCK.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 4** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O00327	Basic helix-loop-helix ARNT-like protein 1	ARNTL BHLHE5 BMAL1 MOP3 PASD3	view
O15516	Circadian locomoter output cycles protein kaput	BHLHE8 CLOCK KIAA0334	view
Q03164	Histone-lysine N-methyltransferase 2A	ALL1 CXXC7 HRX HTRX KMT2A MLL MLL1 TRX1	view
Q92793	CREB-binding protein	CBP CREBBP	view

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