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The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9931521

PubChem

R-HSA-9931521

Description

A complex containing Cryptochrome proteins CRY1, CRY2, Period proteins PER1, PER2, PER3, and kinases CSNK1D and/or CSNK1E binds a heterodimer containing phosphorylated CLOCK and phosphorylated, acetylated BMAL1 bound to E-boxes in the promoters of target genes (inferred from mouse homologs in Griffin et al. 1999, Langmesser et al. 2008, Ye et al. 2011, Ye et al. 2014, Aryal et al. 2017, Cao et al. 2021). This effectively delivers the kinases CSNK1D and/or CSNK1E to the proximity of CLOCK, resulting in further phosphorylation of CLOCK (inferred from mouse homologs in Cao et al. 2021). NPAS2, which acts redundantly with CLOCK, may be similarly phosphorylated. The phosphorylation of CLOCK causes the dissociation of the BMAL1:CLOCK heterodimer from DNA (inferred from mouse homologs in Ye et al. 2014, Chiou et al. 2016, Cao et al. 2021), terminating the diurnal activation of gene expression by BMAL1:CLOCK.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 7** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O00327	Basic helix-loop-helix ARNT-like protein 1	ARNTL BHLHE5 BMAL1 MOP3 PASD3	view
O15055	Period circadian protein homolog 2	KIAA0347 PER2	view
O15516	Circadian locomoter output cycles protein kaput	BHLHE8 CLOCK KIAA0334	view
O15534	Period circadian protein homolog 1	KIAA0482 PER PER1 RIGUI	view
P56645	Period circadian protein homolog 3	GIG13 PER3	view
Q03164	Histone-lysine N-methyltransferase 2A	ALL1 CXXC7 HRX HTRX KMT2A MLL MLL1 TRX1	view
Q92793	CREB-binding protein	CBP CREBBP	view

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