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Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9931529

PubChem

R-HSA-9931529

Description

Post-translational modifications of circadian clock proteins provide additional levels of tempo control and metabolic control, as well as mechanisms for terminating transcriptional activation and activating proteolysis (reviewed in Lee et al. 2001, Hirano et al 2016, Alessandro et al. 2019).
After BMAL1 (ARNTL) and CLOCK are synthesized in the cytosol, CDK5 phosphorylates CLOCK (inferred from mouse homologs in Kwak et al. 2013) and CSNK2A1 (CK2alpha) phosphorylates BMAL1 (inferred from mouse homologs in Tamaru et al. 2009, Tamaru et al. 2015). The phosphorylated BMAL1 and CLOCK proteins heterodimerize (inferred from mouse homologs in Kondratov et al. 2003, Tamaru et al 2015) and are translocated to the nucleoplasm (inferred from mouse homologs in Tamaru et al. 2003, Kondratov et al. 2006, Kwon et al. 2006). NPAS2 can also heterodimerize with BMAL1 (Reick et al. 2001) and is presumed to undergo similar phosphorylation, however, this has not been directly demonstrated.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 4** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O00327	Basic helix-loop-helix ARNT-like protein 1	ARNTL BHLHE5 BMAL1 MOP3 PASD3	view
O15516	Circadian locomoter output cycles protein kaput	BHLHE8 CLOCK KIAA0334	view
P68400	Casein kinase II subunit alpha	CK2A1 CSNK2A1	view
Q00535	Cyclin-dependent kinase 5	CDK5 CDKN5 PSSALRE	view

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