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Degradation of CRY and PER proteins

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9932298

PubChem

R-HSA-9932298

Description

In order to initiate a new round of transcription activated by BMAL1:CLOCK in the morning, Cryptochrome proteins (CRY1, CRY2) and Period proteins (PER1, PER2, PER3), the repressors of BMAL:CLOCK, are ubiquitinylated by SCF E3 ligase complexes and then proteolyzed by the 26S proteasome during the night. The BTRC,FBXW11:CUL1:SKP1:RBX1 E3 ligase complex ubiquitinylates phosphorylated PER1, PER2, and likely PER3 in the cytosol (Shirogane et al. 2005, inferred from mouse homologs in Reischl et al. 2007, Ohsaki et al. 2008), the FBXL3:CUL1:SKP1:RBX1 E3 ligase complex ubiquitinylates CRY1 and CRY2 in the nucleoplasm (inferred from mouse homologs in Busino et al. 2007, Hirano et al. 2013, Yoo et al. 2013), and the FBXL21:CUL1:SKP1:RBX1 E3 ligase complex ubiquitinylates CRY1 and CRY2 in the cytosol (inferred from mouse homologs in Hirano et al. 2013, Yoo et al. 2013). FBLX21 represses ubiquitinylation by FBXL3 in the nucleus by an uncharacterized mechanism (inferred from mouse homologs in Hirano et al. 2013, Yoo et al. 2013)

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 25 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O00231	26S proteasome non-ATPase regulatory subunit 11	PSMD11	view
O00487	Ubiquitin C-terminal hydrolase PSMD14	POH1 PSMD14	view
O14818	Proteasome subunit alpha type-7	HSPC PSMA7	view
O15055	Period circadian protein homolog 2	KIAA0347 PER2	view
O15534	Period circadian protein homolog 1	KIAA0482 PER PER1 RIGUI	view
O43242	26S proteasome non-ATPase regulatory subunit 3	PSMD3	view
P17980	26S proteasome regulatory subunit 6A	PSMC3 TBP1	view
P20618	Proteasome subunit beta type-1	PSC5 PSMB1	view
P25786	Proteasome subunit alpha type-1	HC2 NU PROS30 PSC2 PSMA1	view
P25788	Proteasome subunit alpha type-3	HC8 PSC8 PSMA3	view

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