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CHD6, CHD7, CHD8, CHD9 subfamily

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9943962

PubChem

R-HSA-9943962

Description

CHD6, CHD7, CHD8 and CHD9 make up subfamily III, based on their orthology to the founding member in Drosophila, Kismet (Tamkun et al, 1992, Daubresse et al, 1999). Like subfamily I and II proteins, subfamily III proteins have tandem N-terminal chromodomains and a SNF2 ATPase domain, but also have additional C-terminal motifs including a Brahma-Kismet (BRK) domain, a SANT motif, and a DNA-binding region (reviewed in Marfella and Imbalzano, 2007; Alendar and Berns, 2021). The function of the BRK domain, so named because of its identification in the Drosophila Brahma and Kismet proteins, is not elucidated but it may play a role in binding CTCF (Allen et al, 2007; Ishihara et al, 2006). Like other CHD proteins, subfamily III is implicated in regulation of transcription, proliferation and repair of DNA damage (reviewed in Alendar and Berns, 2021). Although CHD6-9 are 50-54% identical, they appear to have distinct biochemical characteristics and to play non-redundant biological roles (Manning and Yusufzai, 2017; reviewed in Mills et al, 2017).

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SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 34 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O60675	Transcription factor MafK	MAFK	view
O60814	Histone H2B type 1-K	H2BC12 H2BFT HIRIP1 HIST1H2BK	view
P01344	Insulin-like growth factor 2	IGF-2 IGF2 PP1446	view
P04908	Histone H2A type 1-B/E	H2AC4; H2AC8 H2AFA H2AFM HIST1H2AB HIST1H2AE	view
P06899	Histone H2B type 1-J	H2BC11 H2BFR HIST1H2BJ	view
P16104	Histone H2AX	H2AFX H2AX	view
P23527	Histone H2B type 1-O	H2BC17 H2BFH H2BFN HIST1H2BO	view
P33778	Histone H2B type 1-B	H2BC3 H2BFF HIST1H2BB	view
P35222	Catenin beta-1	CTNNB CTNNB1 OK/SW-cl.35 PRO2286	view
P49711	Transcriptional repressor CTCF	CTCF	view

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