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MIRAGE
MAP3K8 (TPL2)-dependent MAPK1/3 activation

Summary
Species
Mus musculus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
Nfkb1NFKB1:MAP3K8:TNIP2MAP3K8TNIP2ADPATPNFKB1:p-S400-MAP3K8:TNIP2NFKB1:p-T290-MAP3K8:TNIP2p-S927,S932-NFKB1(1-968):MAP3K8:TNIP2p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2CUL1:FBXW11:SKP13xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2UbQ07174
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
Displaying all 3 entries
UniProt ID Protein Name Gene Symbol Pathway Viewer
O88351 Inhibitor of nuclear factor kappa-B kinase subunit beta
  • Ikbkb
  • Ikkb
 view
P0CG49 Polyubiquitin-B
  • Ubb
 view
P25799 Nuclear factor NF-kappa-B p105 subunit
  • Nfkb1
 view
If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025