metabolic dysfunction and alcohol associated liver disease

Summary
Synonym
  • MetALD
  • metabolic dysfunction and alcohol related liver disease
Definition
A steatotic liver disease characterized by at least one of five specified cardiometabolic risk factors and elevated alcohol consumption. This disease is distinguished from MASLD by increased alcohol consumption and from ALD by the evidence of one or more of the specified cardiometabolic risk factors. The five cardiometabolic risk factors are: (1) higher than normal body mass index or waist circumference; (2) higher than normal serum glucose or glycated hemoglobin level, or type 2 diabetes; (3) higher than normal blood pressure or hypertensive treatment; (4) higher than normal plasma triglycerides or lipid lowering treatment; and (5) lower than normal plasma high-density lipoprotein cholesterol.
Super Class
steatotic liver disease
Disease Ontology
DOID:0070508
Related Genes
Displaying all 2 entries
Gene ID Gene Symbol Description Source
217 ALDH2 aldehyde dehydrogenase 2 family member
7124 TNF tumor necrosis factor
Displaying 1 entry
Gene ID Gene Symbol Description Source
29539 Aldh2 aldehyde dehydrogenase 2 family member
Related Glycoprotein

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025