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MIRAGE
graft-versus-host disease
Summary
- Synonym
-
- GvHD
- graft versus host disease
- Definition
- An immune system disease that is characterized by recognition by mature donor T cells, that contaminate the allogeneic bone marrow, of the recipient's tissue as foreign, causing a severe inflammatory disease characterized by rashes, diarrhea, and liver disease, and that has_material_basis_in an associated with variation in the interleukin-10 gene (IL10) on chromosome 1q32.
- Super Class
- immune system disease
External Links
- Disease Ontology
- DOID:0081267
- Mondo Disease Ontology
- MeSH
- ORDO
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 28 | ABO | ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase | |
| 1493 | CTLA4 | cytotoxic T-lymphocyte associated protein 4 | |
| 2214 | FCGR3A | Fc gamma receptor IIIa | |
| 3082 | HGF | hepatocyte growth factor | |
| 3115 | HLA-DPB1 | major histocompatibility complex, class II, DP beta 1 | |
| 3458 | IFNG | interferon gamma | |
| 3552 | IL1A | interleukin 1 alpha | |
| 3557 | IL1RN | interleukin 1 receptor antagonist | |
| 3558 | IL2 | interleukin 2 | |
| 3586 | IL10 | interleukin 10 |
Related Glycoprotein
| UniProt ID | Protein Name | Source |
|---|---|---|
| P60568 | Interleukin-2 | |
| Q08334 | Interleukin-10 receptor subunit beta | |
| Q9HC29 | Nucleotide-binding oligomerization domain-containing protein 2 |
