primary angle-closure glaucoma

Summary
Synonym
  • primary Angle Closure Glaucoma
Definition
An angle-closure glaucoma characterized by closure of the anterior chamber angle by an intrinsic defect such that aqueous outflow is blocked and the intraocular pressure becomes inappropriately elevated leading to optic nerve damage and visual field loss. Primary angle-closure glaucoma has_symptom progressive peripheral vision loss, decreased vision, and pain, redness, and headache in acute cases. Primary angle closure glaucoma can be caused by anatomically narrow angle, defects in the trabecular meshwork, and iris abnormalities. Primary angle-closure glaucoma has a strong genetic component.
Super Class
angle-closure glaucoma
Disease Ontology
DOID:1405
Mondo Disease Ontology
UMLS
WikiPathways (from TogoID)
Related Genes
Displaying all 3 entries
Gene ID Gene Symbol Description Source
90 ACVR1 activin A receptor type 1
745 MYRF myelin regulatory factor
80781 COL18A1 collagen type XVIII alpha 1 chain

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025