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myelin regulatory factor

Summary

Gene Symbol

MYRF

Organism

Homo sapiens (human)

External Links

NCBI Gene

745

PubChem

745

Alliance of Genome Resources

HGNC:1181

JoGo

MYRF

TogoVar

MYRF

Annotation

Keyword

3D-structure
Acetylation
Activator
Alternative splicing
Autocatalytic cleavage
Coiled coil
Cytoplasm
DNA-binding
Differentiation
Disease variant
Endoplasmic reticulum
Glycoprotein
Nucleus
Protease
Proteomics identification
Reference proteome
Transcription regulation
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y2G1	Myelin gene regulatory factor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
regulation of DNA-templated transcription	IEA
regulation of transcription, DNA-templated	IEA
oligodendrocyte development	ISS
protein autoprocessing	ISS
protein autoprocessing	IBA

GO Hierarchy

biological process

cellular process [inference]

ensheathment of neurons [inference]

axon ensheathment [inference]

axon ensheathment in central nervous system [inference]

central nervous system myelination

myelination [inference]

central nervous system myelination

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

protein autoprocessing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

protein autoprocessing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation [inference]

oligodendrocyte differentiation

cell development [inference]

glial cell development [inference]

oligodendrocyte development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

plasma membrane organization [inference]

myelin maintenance [inference]

central nervous system myelin maintenance

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

glial cell development [inference]

oligodendrocyte development

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation [inference]

oligodendrocyte differentiation

cell development [inference]

glial cell development [inference]

oligodendrocyte development

response to stimulus [inference]

response to stress [inference]

response to immobilization stress

response to chemical [inference]

response to nitrogen compound [inference]

response to alkaloid [inference]

response to cocaine

response to oxygen-containing compound [inference]

response to cocaine

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of myelination

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system process [inference]

positive regulation of myelination

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

regulation of glial cell differentiation [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

regulation of oligodendrocyte differentiation [inference]

positive regulation of oligodendrocyte differentiation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of myelination [inference]

positive regulation of myelination

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of myelination [inference]

positive regulation of myelination

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

regulation of glial cell differentiation [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

regulation of oligodendrocyte differentiation [inference]

positive regulation of oligodendrocyte differentiation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of myelination

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

positive regulation of nervous system process [inference]

positive regulation of myelination

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system process [inference]

positive regulation of myelination

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of myelination [inference]

positive regulation of myelination

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
nucleus	ISS
nucleus	EXP
nucleus	IBA
nucleus	IEA
nucleoplasm

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
DNA-binding transcription factor activity, RNA polymerase II-specific
DNA binding	ISS
DNA binding	IEA
DNA-binding transcription factor activity	ISS
DNA-binding transcription factor activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

binding [inference]

nucleic acid binding [inference]

DNA binding

sequence-specific DNA binding

protein binding [inference]

identical protein binding

transcription regulator activity [inference]

DNA-binding transcription factor activity

DNA-binding transcription factor activity, RNA polymerase II-specific

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

myelin regulatory factor

Functional Category

L: Replication, recombination and repair
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
protein autoprocessing
sequence-specific DNA binding

Displaying **all 4** entries
InterPro
Intramolecular chaperone auto-processing domain
Myelin gene regulatory factor, ICA domain
NDT80 DNA-binding domain
p53-like transcription factor, DNA-binding domain superfamily

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0080634	nanophthalmos	Alliance of Genome Resources
DOID:1405	primary angle-closure glaucoma	Alliance of Genome Resources
DOID:3526	cerebral infarction	Alliance of Genome Resources
DOID:3827	congenital diaphragmatic hernia	Alliance of Genome Resources
DOID:9834	hyperopia	Alliance of Genome Resources