multiple sclerosis

Summary
Synonym
  • Generalized multiple sclerosis
  • insular sclerosis
Definition
A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring.
Super Class
autoimmune disease of central nervous system demyelinating disease
Disease Ontology
DOID:2377
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
GARD
MGI genotype (from TogoID)
WikiPathways (from TogoID)
Related Genes
Displaying entries 31 - 40 of 55 in total
Gene ID Gene Symbol Description Source
4318 MMP9 matrix metallopeptidase 9
4321 MMP12 matrix metallopeptidase 12
4340 MOG myelin oligodendrocyte glycoprotein
4720 NDUFS2 NADH:ubiquinone oxidoreductase core subunit S2
4855 NOTCH4 notch receptor 4
5133 PDCD1 programmed cell death 1
5551 PRF1 perforin 1
5788 PTPRC protein tyrosine phosphatase receptor type C
5819 NECTIN2 nectin cell adhesion molecule 2
6346 CCL1 C-C motif chemokine ligand 1
Displaying all 2 entries
Gene ID Gene Symbol Description Source
18646 Prf1 perforin 1 (pore forming protein)
21926 Tnf tumor necrosis factor

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Last updated: December 8, 2025