glioblastoma

Summary
Synonym
  • GBM
  • adult glioblastoma multiforme
  • glioblastoma multiforme
  • grade IV adult Astrocytic tumor
  • primary glioblastoma multiforme
  • spongioblastoma multiforme
Definition
A malignant astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has_material_basis_in abnormally proliferating cells derives_from multiple cell types including astrocytes and oligondroctyes.
Super Class
malignant astrocytoma
Disease Ontology
DOID:3068
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
GARD
MGI genotype (from TogoID)
WikiPathways (from TogoID)
Related Genes
Displaying entries 11 - 19 of 19 in total
Gene ID Gene Symbol Description Source
4893 NRAS NRAS proto-oncogene, GTPase
5155 PDGFB platelet derived growth factor subunit B
5159 PDGFRB platelet derived growth factor receptor beta
5228 PGF placental growth factor
5291 PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5787 PTPRB protein tyrosine phosphatase receptor type B
5925 RB1 RB transcriptional corepressor 1
7515 XRCC1 X-ray repair cross complementing 1
10000 AKT3 AKT serine/threonine kinase 3
Displaying 1 entry
Gene ID Gene Symbol Description Source
22059 Trp53 transformation related protein 53
Displaying 1 entry
Gene ID Gene Symbol Description Source
295703 Serping1 serpin family G member 1

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 4, 2025