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MIRAGE
amyotrophic lateral sclerosis

Summary
Synonym
  • ALS
  • Lou Gehrig's disease
  • motor neuron disease, bulbar
Definition
A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing.
Super Class
motor neuron disease
Disease Ontology
DOID:332
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
ORDO
GARD
MGI genotype (from TogoID)
WikiPathways (from TogoID)
Related Genes
Displaying entries 21 - 24 of 24 in total
Gene ID Gene Symbol Description Source
23025 UNC13A unc-13 homolog A
23435 TARDBP TAR DNA binding protein
25978 CHMP2B charged multivesicular body protein 2B
29978 UBQLN2 ubiquilin 2
Displaying all 3 entries
Gene ID Gene Symbol Description Source
24588 Nefm neurofilament medium chain
29152 Mstn myostatin
113959 C5ar1 complement C5a receptor 1
Displaying 1 entry
Gene ID Gene Symbol Description Source
175502 tir-1 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase;NAD(+) hydrolase tir-1;Sterile alpha and TIR motif-containing protein 1
Related Glycoprotein
Displaying 1 entry
UniProt ID Protein Name Source
O88466 Zinc finger protein 106
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025