systemic scleroderma

Summary
Synonym
  • Scleroderma
  • Scleroderma syndrome
  • progressive systemic sclerosis
  • systemic sclerosis
Definition
A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies.
Super Class
scleroderma
Disease Ontology
DOID:418
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
GARD
MGI genotype (from TogoID)
Related Genes
Displaying entries 11 - 17 of 17 in total
Gene ID Gene Symbol Description Source
4049 LTA lymphotoxin alpha
4314 MMP3 matrix metallopeptidase 3
4318 MMP9 matrix metallopeptidase 9
4855 NOTCH4 notch receptor 4
6556 SLC11A1 solute carrier family 11 member 1
6775 STAT4 signal transducer and activator of transcription 4
149233 IL23R interleukin 23 receptor
Displaying all 4 entries
Gene ID Gene Symbol Description Source
12825 Col3a1 collagen, type III, alpha 1
14118 Fbn1 fibrillin 1
14284 Fosl2 fos-like antigen 2
21812 Tgfbr1 transforming growth factor, beta receptor I

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: December 8, 2025