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complement C8 alpha chain

Summary

Gene Symbol

Organism

Oryctolagus cuniculus (rabbit)

External Links

NCBI Gene: 100009076
PubChem: 100009076

Annotation

Keyword

Calcium
Complement alternate pathway
Direct protein sequencing
Disulfide bond
EGF-like domain
Glycoprotein
Membrane attack complex
Metal-binding
Reference proteome
Repeat
Secreted
Signal
Target cell membrane
Transmembrane beta strand

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A5F9CGU8
P98136	Complement component 8 subunit alpha

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
complement activation	IEA	30032202
complement activation, alternative pathway
complement activation, classical pathway
killing of cells of another organism

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

activation of immune response [inference]

complement activation

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response [inference]

complement activation, alternative pathway

cellular process [inference]

cell killing [inference]

killing of cells of another organism

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response [inference]

complement activation, alternative pathway

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
membrane attack complex	IEA	22301074 30032202
extracellular space	IEA	30032202

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

pore complex [inference]

membrane attack complex

plasma membrane protein complex [inference]

membrane attack complex

cellular anatomical entity [inference]

extracellular space

Displaying 1 entry
GO Term	Evidence Code	PMID
protein binding	IEA	22301074

GO Hierarchy

molecular function

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

complement component c8 beta chain

Functional Category

O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 4** entries
Gene Ontology
complement activation, classical pathway
complement activation
immune response
immune system process

Displaying **all 9** entries
InterPro
Complement components C8A/B/C6, EGF-like domain
LDL receptor-like superfamily
Low-density lipoprotein (LDL) receptor class A repeat
Low-density lipoprotein (LDL) receptor class A, conserved site
Membrane attack complex component/perforin (MACPF) domain
Membrane attack complex component/perforin domain, conserved site
Membrane attack complex component/perforin/complement C9
Thrombospondin type-1 (TSP1) repeat superfamily
Thrombospondin type-1 (TSP1) repeat

Ortholog

Displaying entries **11 - 20** of 91 in total

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Species	Gene ID	Orthologous MAtrix
Callithrix jacchus	100396921	CALJA39735
Pongo abelii	100454371	PONAB17774
Ailuropoda melanoleuca	100479782	AILME01289
Anolis carolinensis	100563663	ANOCA06091
Nomascus leucogenys	100582717	NOMLE30990
Loxodonta africana	100660679	LOXAF13550
Oreochromis niloticus	100694264	ORENI28857
Cavia porcellus	100729882	CAVPO21136
Cricetulus griseus	100774244	CRIGR01042
Canis lupus familiaris	100855712	CANLF15664

GlyTouCan

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OrthoDB (Group)

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Acknowledgements