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MIRAGE

UDP-glucose 6-dehydrogenase

Summary

Gene Symbol

UGDH

Organism

Ochotona princeps (American pika)

External Links

NCBI Gene: 101521290
KEGG Gene ID: opi:101521290
PubChem: 101521290

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
glycosaminoglycan biosynthetic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
nucleus	IEA	30032202
cytosol	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
UDP-glucose 6-dehydrogenase activity	IEA	22301074 30032202
NAD binding	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

UDP-glucose 6-dehydrogenase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

udp-glucose 6-dehydrogenase

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
M: Cell wall/membrane/envelope biogenesis

Displaying **all 5** entries
Gene Ontology
UDP-glucose 6-dehydrogenase activity
UDP-glucuronate biosynthetic process
glycosaminoglycan biosynthetic process
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
oxidoreductase activity

Displaying **all 8** entries
InterPro
6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
NAD(P)-binding domain superfamily
UDP-glucose 6-dehydrogenase, eukaryotic type
UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily
UDP-glucose/GDP-mannose dehydrogenase, C-terminal
UDP-glucose/GDP-mannose dehydrogenase, N-terminal
UDP-glucose/GDP-mannose dehydrogenase, dimerisation
UDP-glucose/GDP-mannose dehydrogenase

KEGG BRITE Database

Orthology

K00012

Name

UDPglucose 6-dehydrogenase [EC:1.1.1.22]

References

21961565

Ortholog

Displaying entries **61 - 70** of 79 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Crocodylus porosus	109322206		CROPO11492
Phascolarctos cinereus	110211819		PHACI24648
Pseudonaja textilis	113435785		PSETE06618
Athene cunicularia	113479351		ATHCN07911
Bos indicus x Bos taurus	113894222		BOBOX04179
Vombatus ursinus	114023846		VOMUR02469
Podarcis muralis	114604768		PODMU30091
Echeneis naucrates	115041419		ECHNA16391
Salarias fasciatus	115390584		SALFA20350
Gadus morhua	115540832		GADMO41492

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025