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centromere protein C

Summary

Gene Symbol

CENPC

Organism

Homo sapiens (human)

External Links

NCBI Gene

1060

PubChem

1060

Alliance of Genome Resources

HGNC:1854

Annotation

Keyword

3D-structure
Alternative splicing
Centromere
Chromosome
DNA-binding
Isopeptide bond
Kinetochore
Mitosis
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q03188	Centromere autoantigen C Centromere protein C 1 Interphase centromere complex protein 7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
mitotic cell cycle	IMP	21529714
chromosome segregation	NAS	36085283
chromosome segregation	IMP	21529714
cell division	IEA
attachment of mitotic spindle microtubules to kinetochore	IBA

GO Hierarchy

biological process

cellular process [inference]

cell cycle [inference]

mitotic cell cycle

cell cycle process [inference]

chromosome segregation

attachment of spindle microtubules to kinetochore [inference]

attachment of mitotic spindle microtubules to kinetochore

attachment of meiotic spindle microtubules to kinetochore [inference]

spindle attachment to meiosis I kinetochore

meiotic cell cycle process [inference]

attachment of meiotic spindle microtubules to kinetochore [inference]

spindle attachment to meiosis I kinetochore

mitotic cell cycle process [inference]

attachment of mitotic spindle microtubules to kinetochore

cell division

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

kinetochore organization [inference]

kinetochore assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

kinetochore assembly

cellular component assembly [inference]

protein-containing complex assembly [inference]

kinetochore assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

kinetochore assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

kinetochore assembly

reproductive process [inference]

meiotic cell cycle process [inference]

attachment of meiotic spindle microtubules to kinetochore [inference]

spindle attachment to meiosis I kinetochore

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
kinetochore	IDA	21529714
condensed chromosome, centromeric region	IDA	11682612
inner kinetochore	IPI	36085283
nucleus	NAS	36085283
nucleoplasm	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

inner kinetochore

protein-DNA complex [inference]

chromatin [inference]

heterochromatin [inference]

pericentric heterochromatin

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

kinetochore

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

kinetochore

chromosomal region [inference]

chromosome, centromeric region [inference]

condensed chromosome, centromeric region

supramolecular complex [inference]

kinetochore

Displaying **all 4** entries
GO Term	Evidence Code	PMID
DNA binding	TAS	1339310
protein binding	IPI	19503796 27881301 30021884 33961781
centromeric DNA binding	IBA
identical protein binding	IPI	19503796

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

double-stranded DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

centromeric DNA binding

sequence-specific DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

centromeric DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Centromere protein C

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
centromeric DNA binding
spindle attachment to meiosis I kinetochore

Displaying **all 4** entries
InterPro
Centromere protein C/Mif2/cnp3
Mif2/CENP-C cupin domain
RmlC-like cupin domain superfamily
RmlC-like jelly roll fold

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060218	CREST syndrome	Alliance of Genome Resources
DOID:5082	liver cirrhosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 48 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	1060	Xenbase:XB-GENE-6452278
Mus musculus	12617		MOUSE44945
Rattus norvegicus	305270		RATNO07714
Ovis aries	443459		SHEEP17393
Bos taurus	450214		BOVIN31568
Pan troglodytes	461295		PANTR33886
Canis lupus familiaris	475158		CANLF03431
Macaca mulatta	710620		MACMU37347
Equus caballus	100067221		HORSE31769
Oryctolagus cuniculus	100345012		RABIT05397

GlyTouCan

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements