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Centromere protein C

Summary

UniProt ID

Q03188

Gene Symbol

CENPC
CENPC1
ICEN7

Gene ID

[1060]

Organism

Homo sapiens (human)

External Links

GlyGen: Q03188
PubChem: Q03188
The O-GlcNAc Database: Q03188
O-GlcNAcAtlas: Q03188
Re-Glyco: Q03188

Annotation

Keyword: 3D-structure Alternative splicing Centromere Chromosome DNA-binding Isopeptide bond Kinetochore Mitosis Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	Reference
mitotic cell cycle	IMP	PMID
mitotic cell cycle	IEA	GO_REF
chromosome segregation	NAS	PMID
chromosome segregation	IMP	PMID
chromosome segregation	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

cell cycle [inference]

mitotic cell cycle

cell cycle process [inference]

chromosome segregation

attachment of spindle microtubules to kinetochore [inference]

attachment of mitotic spindle microtubules to kinetochore

attachment of meiotic spindle microtubules to kinetochore [inference]

spindle attachment to meiosis I kinetochore

meiotic cell cycle process [inference]

attachment of meiotic spindle microtubules to kinetochore [inference]

spindle attachment to meiosis I kinetochore

mitotic cell cycle process [inference]

attachment of mitotic spindle microtubules to kinetochore

cell division

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

kinetochore organization [inference]

kinetochore assembly

organelle assembly [inference]

membraneless organelle assembly [inference]

kinetochore assembly

cellular component assembly [inference]

protein-containing complex assembly [inference]

kinetochore assembly

organelle assembly [inference]

membraneless organelle assembly [inference]

kinetochore assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

kinetochore assembly

reproductive process [inference]

meiotic cell cycle process [inference]

attachment of meiotic spindle microtubules to kinetochore [inference]

spindle attachment to meiosis I kinetochore

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	Reference
kinetochore	TAS	PMID
kinetochore	IDA	PMID GO_REF
kinetochore	IEA	GO_REF
condensed chromosome, centromeric region	IDA	PMID
condensed chromosome, centromeric region	IEA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

inner kinetochore

cellular anatomical structure [inference]

chromatin [inference]

heterochromatin [inference]

pericentric heterochromatin

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

chromosomal region [inference]

chromosome, centromeric region [inference]

condensed chromosome, centromeric region

supramolecular complex [inference]

kinetochore

Displaying **all 5** entries
GO Term	Evidence Code	Reference
DNA binding	TAS	PMID
DNA binding	IEA	GO_REF
centromeric DNA binding	IBA	GO_REF
centromeric DNA binding	IEA	GO_REF
identical protein binding	IPI	PMID

GO Hierarchy

molecular function

binding [inference]

nucleic acid binding [inference]

DNA binding

double-stranded DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

centromeric DNA binding

sequence-specific DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

centromeric DNA binding

protein binding [inference]

identical protein binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MAASGLDHLKNGYRRRFCRPSRARDINTEQGQNVLEILQDCFEEKSLANDFSTNSTKSVPNSTRKIKDTCIQSPSKECQKSHPKSVPVSSKKKEASLQFVVEPSEATNRSVQAHEVHQKILATDVSSKNTPDSKKISSRNINDHHSEADEEFYLSVGSPSVLLDAKTSVSQNVIPSSAQKRETYTFENSVNMLPSSTEVSVKTKKRLNFDDKVMLKKIEIDNKVSDEEDKTSEGQERKPSGSSQNRIRDSEYEIQRQAKKSFSTLFLETVKRKSESSPIVRHAATAPPHSCPPDDTKLIEDEFIIDESDQSFASRSWITIPRKAGSLKQRTISPAESTALLQGRKSREKHHNILPKTLANDKHSHKPHPVETSQPSDKTVLDTSYALIGETVNNYRSTKYEMYSKNAEKPSRSKRTIKQKQRRKFMAKPAEEQLDVGQSKDENIHTSHITQDEFQRNSDRNMEEHEEMGNDCVSKKQMPPVGSKKSSTRKDKEESKKKRFSSESKNKLVPEEVTSTVTKSRRISRRPSDWWVVKSEESPVYSNSSVRNELPMHHNSSRKSTKKTNQSSKNIRKKTIPLKRQKTATKGNQRVQKFLNAEGSGGIVGHDEISRCSLSEPLESDEADLAKKKNLDCSRSTRSSKNEDNIMTAQNVPLKPQTSGYTCNIPTESNLDSGEHKTSVLEESGPSRLNNNYLMSGKNDVDDEEVHGSSDDSKQSKVIPKNRIHHKLVLPSNTPNVRRTKRTRLKPLEYWRGERIDYQGRPSGGFVISGVLSPDTISSKRKAKENIGKVNKKSNKKRICLDNDERKTNLMVNLGIPLGDPLQPTRVKDPETREIILMDLVRPQDTYQFFVKHGELKVYKTLDTPFFSTGKLILGPQEEKGKQHVGQDILVFYVNFGDLLCTLHETPYILSTGDSFYVPSGNYYNIKNLRNEESVLLFTQIKR

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	PubMed ID	GlyTouCan ID	Source
54		G59324HL	GlyGen
543		G41247ZX	GlyGen
568	30379171 40596516	G49108TO	GlyGen The O-GlcNAc Database
743	30379171 40596516	G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 7** entries
Pathway Name	Organism
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	Homo sapiens
Deposition of new CENPA-containing nucleosomes at the centromere	Homo sapiens
EML4 and NUDC in mitotic spindle formation	Homo sapiens
Mitotic Prometaphase	Homo sapiens
RHO GTPases Activate Formins	Homo sapiens
Resolution of Sister Chromatid Cohesion	Homo sapiens
Separation of Sister Chromatids	Homo sapiens

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:5082	liver cirrhosis	Alliance of Genome Resources
DOID:0060218	CREST syndrome	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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