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Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-141444

PubChem

R-HSA-141444

Description

The signal from unattached kinetochores is amplified through a Mad2 inhibitory signal that is propagated by the binding of Mad1 to the kinetochore, the association of Mad2 with Mad1, the conversion of Mad2 conformation to an inhibitory form through its association with Mad1 and finally the release of the inhibitory form of Mad2 from the kinetochore.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 43 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O00139	Kinesin-like protein KIF2A	KIF2 KIF2A KNS2	view
O14576	Cytoplasmic dynein 1 intermediate chain 1	DNCI1 DNCIC1 DYNC1I1	view
O14980	Exportin-1	CRM1 XPO1	view
O43237	Cytoplasmic dynein 1 light intermediate chain 2	DNCLI2 DYNC1LI2 LIC2	view
O43264	Centromere/kinetochore protein zw10 homolog	ZW10	view
O43683	Mitotic checkpoint serine/threonine-protein kinase BUB1	BUB1 BUB1L	view
O43684	Mitotic checkpoint protein BUB3	BUB3	view
O60566	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	BUB1B BUBR1 MAD3L SSK1	view
O75122	CLIP-associating protein 2	CLASP2 KIAA0627	view
P30153	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform	PPP2R1A	view

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