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Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

Summary

UniProt ID: P30153
Gene Symbol: PPP2R1A
Gene ID: 5518
Organism: Homo sapiens (human)

External Links

GlyGen: P30153
PubChem: P30153
The O-GlcNAc Database: P30153
RaftProt: P30153
O-GlcNAcAtlas: P30153
Re-Glyco: P30153

Annotation

Keyword: 3D-structure Acetylation Cell membrane Cell projection Centromere Chromosome Chromosome partition Cytoplasm Direct protein sequencing Disease variant Host-virus interaction Intellectual disability Nucleus Proteomics identification Reference proteome Repeat

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	Reference
chromosome segregation	IDA	PMID
female meiotic nuclear division
negative regulation of hippo signaling	IDA	PMID
intracellular signal transduction	NAS	PMID
regulation of growth	NAS	PMID

GO Hierarchy

biological process

immune system process [inference]

leukocyte homeostasis [inference]

lymphocyte homeostasis [inference]

T cell homeostasis

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

spindle organization [inference]

spindle assembly

spindle elongation [inference]

meiotic spindle elongation

signal transduction [inference]

intracellular signal transduction

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

RNA surveillance [inference]

nuclear RNA surveillance [inference]

RNA polymerase II transcription initiation surveillance

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

RNA surveillance [inference]

nuclear RNA surveillance [inference]

RNA polymerase II transcription initiation surveillance

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

RNA surveillance [inference]

nuclear RNA surveillance [inference]

RNA polymerase II transcription initiation surveillance

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process [inference]

RNA surveillance [inference]

nuclear RNA surveillance [inference]

RNA polymerase II transcription initiation surveillance

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

RNA surveillance [inference]

nuclear RNA surveillance [inference]

RNA polymerase II transcription initiation surveillance

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

RNA surveillance [inference]

nuclear RNA surveillance [inference]

RNA polymerase II transcription initiation surveillance

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process [inference]

RNA surveillance [inference]

nuclear RNA surveillance [inference]

RNA polymerase II transcription initiation surveillance

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

RNA surveillance [inference]

nuclear RNA surveillance [inference]

RNA polymerase II transcription initiation surveillance

cell cycle process [inference]

spindle organization [inference]

spindle assembly

chromosome segregation

sister chromatid cohesion [inference]

meiotic sister chromatid cohesion [inference]

meiotic sister chromatid cohesion, centromeric

centromeric sister chromatid cohesion [inference]

meiotic sister chromatid cohesion, centromeric

spindle elongation [inference]

meiotic spindle elongation

chromosome separation [inference]

mitotic sister chromatid separation

meiotic cell cycle process [inference]

meiotic spindle elongation

meiotic nuclear division [inference]

female meiotic nuclear division

mitotic cell cycle process [inference]

mitotic sister chromatid separation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

spindle organization [inference]

spindle assembly

organelle fission [inference]

nuclear division [inference]

meiotic nuclear division [inference]

female meiotic nuclear division

chromosome organization [inference]

sister chromatid cohesion [inference]

meiotic sister chromatid cohesion [inference]

meiotic sister chromatid cohesion, centromeric

centromeric sister chromatid cohesion [inference]

meiotic sister chromatid cohesion, centromeric

organelle assembly [inference]

membraneless organelle assembly [inference]

spindle assembly

cellular component assembly [inference]

protein-containing complex assembly

organelle assembly [inference]

membraneless organelle assembly [inference]

spindle assembly

protein-containing complex organization [inference]

protein-containing complex assembly

reproductive process [inference]

meiotic cell cycle process [inference]

meiotic spindle elongation

meiotic nuclear division [inference]

female meiotic nuclear division

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

lymphocyte homeostasis [inference]

T cell homeostasis

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

lymphocyte homeostasis [inference]

T cell homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

negative regulation of hippo signaling

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

regulation of extrinsic apoptotic signaling pathway in absence of ligand [inference]

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

regulation of growth

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

negative regulation of hippo signaling

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

regulation of extrinsic apoptotic signaling pathway in absence of ligand [inference]

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

regulation of developmental process [inference]

regulation of cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

negative regulation of hippo signaling

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

regulation of extrinsic apoptotic signaling pathway in absence of ligand [inference]

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

regulation of extrinsic apoptotic signaling pathway in absence of ligand [inference]

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

regulation of cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of meiotic cell cycle process involved in oocyte maturation

regulation of reproductive process [inference]

regulation of meiotic cell cycle process involved in oocyte maturation

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	Reference
protein phosphatase type 2A complex	TAS	PMID
protein phosphatase type 2A complex	IDA	PMID PMID
protein phosphatase type 2A complex	IBA	GO_REF
protein phosphatase type 2A complex	IPI	PMID PMID PMID PMID PMID PMID
chromosome, centromeric region	IDA	PMID

GO Hierarchy

cellular component

protein-containing complex [inference]

FAR/SIN/STRIPAK complex

nuclear protein-containing complex [inference]

INTAC complex

catalytic complex [inference]

phosphatase complex [inference]

protein serine/threonine phosphatase complex [inference]

protein phosphatase type 2A complex

cellular anatomical structure [inference]

cell junction [inference]

synapse [inference]

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

dendrite

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

cell body [inference]

neuronal cell body

chromosomal region [inference]

chromosome, centromeric region

Displaying **all 5** entries
GO Term	Evidence Code	Reference
protein serine/threonine phosphatase activity
protein phosphatase regulator activity	IDA	PMID PMID
protein phosphatase regulator activity	IBA	GO_REF
protein heterodimerization activity	IPI	PMID
protein antigen binding	IPI	PMID

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

phosphoprotein phosphatase activity [inference]

protein serine/threonine phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity [inference]

protein serine/threonine phosphatase activity

binding [inference]

antigen binding [inference]

protein antigen binding

protein binding [inference]

protein dimerization activity [inference]

protein heterodimerization activity

protein antigen binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

phosphatase regulator activity [inference]

protein phosphatase regulator activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MAAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
553			G62765YT	GlyGen
555		16408927 23301498 23576270 26853435 29351928 32119511 33214551 34019948 34725712 35138101 37217939 38665916 40596516 40914422	G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 45 in total

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Pathway Name	Organism
APC truncation mutants have impaired AXIN binding	Homo sapiens
AURKA Activation by TPX2	Homo sapiens
AXIN missense mutants destabilize the destruction complex	Homo sapiens
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	Homo sapiens
Anchoring of the basal body to the plasma membrane	Homo sapiens
Beta-catenin phosphorylation cascade	Homo sapiens
CD28 co-stimulation	Homo sapiens
CTNNB1 S33 mutants aren't phosphorylated	Homo sapiens
CTNNB1 S37 mutants aren't phosphorylated	Homo sapiens
CTNNB1 S45 mutants aren't phosphorylated	Homo sapiens

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070066	autosomal dominant intellectual developmental disorder 36	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

International Collaboration

Acknowledgements