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Anchoring of the basal body to the plasma membrane

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-5620912

PubChem

R-HSA-5620912

Description

Cilium biogenesis is initiated by the docking of basal bodies, a centriole-derived organelle, to the plasma membrane (reviewed in Reiter et al, 2012). The centriole consists of a multiprotein core surrounded by a ring of nine microtubule triplets; the mother centriole additionally has 'distal' and 'subdistal appendages' that are critical for ciliogenesis (reviewed in Kim and Dynlacht, 2013; Firat-Karalar and Stearns, 2014; Bettencourt-Dias et al, 2011). Basal bodies initiate and anchor the extension of the axonemal microtubules and also associate with secretory vesicles which are thought to provide membrane components for the extension of the ciliary membrane (Sorokin, 1962; Sorokin, 1968; Bachmann-Gagescu et al, 2011; Tanos et al, 2013; reviewed in Ishikawa et al, 2011; Reiter et al, 2012). Basal bodies are attached to the plasma membrane through a proteinaceous network of transition fibers that form part of the 'transition zone' at the ciliary base. The transition zone acts as a selective barrier or ciliary pore, excluding vesicles and limiting the diffusion of proteins and lipids from the cytosol or plasma membrane (Deane et al, 2001; Craige et al, 2010; Garcia-Gonzalo et al, 2011; Ye et al, 2014; Joo et al, 2013; reviewed in Nachury et al, 2010; Hsiao et al, 2012; Reiter et al, 2012). In addition to the transition fibres, the transition zone also consists of the ciliary necklace (a row of protein particles at the ciliary membrane at the base of the cilium) and the Y-links (that connect the axonemal microtubules to the membrane at the ciliary necklace) (Williams et al, 2011; reviewed in Hsiao et al, 2012; Reiter et al, 2012).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 47 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O43303	Centriolar coiled-coil protein of 110 kDa	CCP110 CEP110 CP110 KIAA0419	view
O94927	HAUS augmin-like complex subunit 5	HAUS5 KIAA0841	view
O94986	Centrosomal protein of 152 kDa	CEP152 KIAA0912	view
O95613	Pericentrin	KIAA0402 PCNT PCNT2	view
O95684	Centrosomal protein 43	CEP43 FGFR1OP FOP	view
P04350	Tubulin beta-4A chain	TUBB4 TUBB4A TUBB5	view
P07437	Tubulin beta chain	OK/SW-cl.56 TUBB TUBB5	view
P07900	Heat shock protein HSP 90-alpha	HSP90A HSP90AA1 HSPC1 HSPCA	view
P30153	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform	PPP2R1A	view
P53350	Serine/threonine-protein kinase PLK1	PLK PLK1	view

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