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MIRAGE

cholesteryl ester transfer protein

Summary

Gene Symbol

CETP

Organism

Homo sapiens (human)

External Links

NCBI Gene

1071

PubChem

1071

Alliance of Genome Resources

HGNC:1869

JoGo

CETP

TogoVar

CETP

Annotation

Keyword

3D-structure
Alternative splicing
Atherosclerosis
Cholesterol metabolism
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Lipid transport
Proteomics identification
Reference proteome
Secreted
Signal

Proteins

Displaying **all 4** entries
UniProt	Protein Name
P11597	Lipid transfer protein I
A0A0S2Z3F6	Lipid transfer protein I
A0A0S2Z3I8	Lipid transfer protein I
B4DMZ5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 37 in total

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GO Term	Evidence Code	PMID
triglyceride metabolic process	IDA
triglyceride metabolic process	IBA
lipid transport	IDA
cholesterol metabolic process	IDA
cholesterol metabolic process	IMP

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-containing complex remodeling [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

triglyceride-rich lipoprotein particle remodeling [inference]

very-low-density lipoprotein particle remodeling

protein-lipid complex organization [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

triglyceride-rich lipoprotein particle remodeling [inference]

very-low-density lipoprotein particle remodeling

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

triglyceride-rich lipoprotein particle remodeling [inference]

very-low-density lipoprotein particle remodeling

multicellular organismal process [inference]

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

triglyceride-rich lipoprotein particle remodeling [inference]

very-low-density lipoprotein particle remodeling

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis

acylglycerol homeostasis [inference]

triglyceride homeostasis

phospholipid homeostasis

sterol homeostasis [inference]

cholesterol homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

lipid transport

phospholipid transport

sterol transport [inference]

cholesterol transport

reverse cholesterol transport

acylglycerol transport [inference]

triglyceride transport

organophosphate ester transport [inference]

phospholipid transport

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport

reverse cholesterol transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

positive regulation of phospholipid transport

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

regulation of cholesterol transport [inference]

regulation of phospholipid transport [inference]

positive regulation of phospholipid transport

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

positive regulation of phospholipid transport

regulation of lipid localization [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

positive regulation of phospholipid transport

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

regulation of cholesterol transport [inference]

regulation of phospholipid transport [inference]

positive regulation of phospholipid transport

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

positive regulation of phospholipid transport

positive regulation of biological process [inference]

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

positive regulation of phospholipid transport

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

positive regulation of phospholipid transport

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of macrophage derived foam cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

regulation of cellular process [inference]

regulation of cell differentiation [inference]

regulation of macrophage derived foam cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
extracellular region	EXP
extracellular region	TAS
extracellular region	IDA
extracellular region	IEA
obsolete extracellular space

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-lipid complex [inference]

lipoprotein particle [inference]

plasma lipoprotein particle [inference]

high-density lipoprotein particle

extracellular protein-containing complex [inference]

plasma lipoprotein particle [inference]

high-density lipoprotein particle

cellular anatomical structure [inference]

extracellular region

organelle [inference]

membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
obsolete phospholipid transporter activity
lipid binding	IDA
lipid binding	IEA
cholesterol binding	IDA
cholesterol binding	IBA

GO Hierarchy

molecular function

transporter activity [inference]

lipid transfer activity [inference]

phospholipid transfer activity

sterol transfer activity [inference]

cholesterol transfer activity

binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

phospholipid binding [inference]

phosphatidylcholine binding

triglyceride binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

phosphatidylcholine binding

alcohol binding [inference]

cholesterol binding

quaternary ammonium group binding [inference]

phosphatidylcholine binding

molecular carrier activity [inference]

lipid carrier activity [inference]

lipid transfer activity [inference]

phospholipid transfer activity

sterol transfer activity [inference]

cholesterol transfer activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cholesteryl ester transfer protein

Functional Category

C: Energy production and conversion
K: Transcription
T: Signal transduction mechanisms

Displaying entries **1 - 10** of 18 in total

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Gene Ontology
cholesterol binding
cholesterol metabolic process
high-density lipoprotein particle remodeling
intermembrane lipid transfer
lipid binding
lipid metabolic process
lipid transport
low-density lipoprotein particle remodeling
phosphatidylcholine binding
phosphatidylcholine metabolic process

Displaying **all 4** entries
InterPro
Bactericidal permeability-increasing protein, alpha/beta domain superfamily
Cholesteryl ester transfer
Lipid-binding serum glycoprotein, C-terminal
Lipid-binding serum glycoprotein, N-terminal

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111369	hyperalphalipoproteinemia 1	Alliance of Genome Resources
DOID:3407	carotid artery disease	Alliance of Genome Resources

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026