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YME1 like 1 ATPase

Summary

Gene Symbol

YME1L1

Organism

Homo sapiens (human)

External Links

NCBI Gene

10730

PubChem

10730

Alliance of Genome Resources

HGNC:12843

Annotation

Keyword

ATP-binding
Alternative splicing
Disease variant
Metal-binding
Metalloprotease
Mitochondrion inner membrane
Reference proteome
Transmembrane helix
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96TA2	ATP-dependent metalloprotease FtsH1 Meg-4 Presenilin-associated metalloprotease YME1-like protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
protein quality control for misfolded or incompletely synthesized proteins	IMP	22262461
protein quality control for misfolded or incompletely synthesized proteins	IBA
mitochondrion organization	IMP	22262461 27495975
mitochondrion organization	IBA
cell population proliferation	IMP	22262461

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

mitochondrial protein processing

proteolysis involved in protein catabolic process [inference]

protein quality control for misfolded or incompletely synthesized proteins

protein catabolic process [inference]

mitochondrial protein catabolic process

protein maturation [inference]

protein processing [inference]

mitochondrial protein processing

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

mitochondrial protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

mitochondrial protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

mitochondrial protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

mitochondrial protein processing

proteolysis involved in protein catabolic process [inference]

protein quality control for misfolded or incompletely synthesized proteins

protein catabolic process [inference]

mitochondrial protein catabolic process

protein maturation [inference]

protein processing [inference]

mitochondrial protein processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

mitochondrial protein catabolic process

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

mitochondrial protein processing

proteolysis involved in protein catabolic process [inference]

protein quality control for misfolded or incompletely synthesized proteins

protein catabolic process [inference]

mitochondrial protein catabolic process

protein maturation [inference]

protein processing [inference]

mitochondrial protein processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

mitochondrial protein processing

proteolysis involved in protein catabolic process [inference]

protein quality control for misfolded or incompletely synthesized proteins

protein catabolic process [inference]

mitochondrial protein catabolic process

protein maturation [inference]

protein processing [inference]

mitochondrial protein processing

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

mitochondrial protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

mitochondrial protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

mitochondrial protein catabolic process

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cell population proliferation

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein hexamerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein hexamerization

multicellular organismal process [inference]

stem cell population maintenance [inference]

neuronal stem cell population maintenance

developmental process [inference]

maintenance of cell number [inference]

stem cell population maintenance [inference]

neuronal stem cell population maintenance

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial fusion

positive regulation of developmental process [inference]

positive regulation of mitochondrial fusion

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of mitochondrial fusion [inference]

positive regulation of mitochondrial fusion

positive regulation of developmental process [inference]

positive regulation of mitochondrial fusion

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial fusion

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial fusion

regulation of mitochondrion organization [inference]

regulation of mitochondrial fusion [inference]

positive regulation of mitochondrial fusion

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial fusion

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of mitochondrial fusion

regulation of cell division [inference]

regulation of stem cell division

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
mitochondrion	IDA	27495975
mitochondrion	HTP	34800366
mitochondrial inner membrane	TAS
mitochondrial inner membrane	IDA	22262461
mitochondrial inner membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

nuclear body

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
ATP-dependent peptidase activity	IDA	24315374 27786171 31695197 33237841 36206740
ATP-dependent peptidase activity	IMP	27495975
ATP-dependent peptidase activity	IBA
metalloendopeptidase activity	IEA
protein binding	IPI	26759378

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

ATP-dependent peptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

ATP-dependent peptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATP-dependent peptidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ATP-dependent Zinc metalloprotease ftsh

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
hydrolase activity
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 8** entries
InterPro
AAA ATPase, AAA+ lid domain
AAA+ ATPase domain
ATP-dependent zinc metalloprotease, FtsH
ATPase, AAA-type, conserved site
ATPase, AAA-type, core
P-loop containing nucleoside triphosphate hydrolase
Peptidase M41-like
Peptidase M41

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111436	optic atrophy 11	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 63 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	10730	Xenbase:XB-GENE-1000059
Mus musculus	27377		MOUSE33346
Rattus norvegicus	114217		RATNO13030
Pan troglodytes	450366		PANTR00354
Canis lupus familiaris	477988		CANLF06461
Bos taurus	505118		BOVIN04327
Danio rerio	557907		DANRE30191
Macaca mulatta	714687		MACMU45885
Monodelphis domestica	100019099		MONDO34796
Ornithorhynchus anatinus	100073795		ORNAN05205