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ATP-dependent zinc metalloprotease YME1L1

Summary

UniProt ID: Q96TA2
Gene Symbol: YME1L1 FTSH1 UNQ1868/PRO4304 YME1L
Gene ID: 10730
Organism: Homo sapiens (human)

External Links

GlyGen: Q96TA2
PubChem: Q96TA2
The O-GlcNAc Database: Q96TA2
RaftProt: Q96TA2
O-GlcNAcAtlas: Q96TA2
Re-Glyco: Q96TA2

Annotation

Keyword: ATP-binding Alternative splicing Disease variant Metal-binding Metalloprotease Mitochondrion inner membrane Proteomics identification Reference proteome Transmembrane helix Zinc

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	Reference
protein quality control for misfolded or incompletely synthesized proteins	IMP	PMID
protein quality control for misfolded or incompletely synthesized proteins	IBA	GO_REF
mitochondrion organization	IMP	PMID PMID
mitochondrion organization	IBA	GO_REF
cell population proliferation	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

mitochondrial protein processing

protein catabolic process [inference]

protein maturation [inference]

protein processing [inference]

mitochondrial protein processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

mitochondrial protein processing

protein catabolic process [inference]

protein maturation [inference]

protein processing [inference]

mitochondrial protein processing

cell population proliferation

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein hexamerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein hexamerization

multicellular organismal process [inference]

stem cell population maintenance [inference]

neuronal stem cell population maintenance

developmental process [inference]

maintenance of cell number [inference]

stem cell population maintenance [inference]

neuronal stem cell population maintenance

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrial fusion

positive regulation of developmental process [inference]

positive regulation of mitochondrial fusion

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of mitochondrial fusion [inference]

positive regulation of mitochondrial fusion

positive regulation of developmental process [inference]

positive regulation of mitochondrial fusion

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrial fusion

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrial fusion

regulation of mitochondrion organization [inference]

regulation of mitochondrial fusion [inference]

positive regulation of mitochondrial fusion

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrial fusion

regulation of cell division [inference]

regulation of stem cell division

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
mitochondrion	EXP	PMID
mitochondrion	IDA	PMID GO_REF
mitochondrion	IEA	GO_REF
mitochondrion	HTP	PMID
mitochondrial inner membrane	ISS	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nuclear body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular membraneless organelle [inference]

nuclear body

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
ATP-dependent peptidase activity	IDA	PMID PMID PMID PMID PMID PMID
ATP-dependent peptidase activity	IMP	PMID
ATP-dependent peptidase activity	IBA	GO_REF
ATP-dependent peptidase activity	IEA	GO_REF GO_REF GO_REF
metalloendopeptidase activity	ISS	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

ATP-dependent peptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

ATP-dependent peptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

ATP-dependent activity [inference]

ATP-dependent peptidase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MFSLSSTVQPQVTVPLSHLINAFHTPKNTSVSLSGVSVSQNQHRDVVPEHEAPSSECMFSDFLTKLNIVSIGKGKIFEGYRSMFMEPAKRMKKSLDTTDNWHIRPEPFSLSIPPSLNLRDLGLSELKIGQIDQLVENLLPGFCKGKNISSHWHTSHVSAQSFFENKYGNLDIFSTLRSSCLYRHHSRALQSICSDLQYWPVFIQSRGFKTLKSRTRRLQSTSERLAETQNIAPSFVKGFLLRDRGSDVESLDKLMKTKNIPEAHQDAFKTGFAEGFLKAQALTQKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTILGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTYSDTGKLSPETQSAIEQEIRILLRDSYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQIVLEGKKLEVR

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 10** entries
Position	PubMed ID	GlyTouCan ID	Source
28		G62765YT	GlyGen
115	28510447 33465208 40596516	G49108TO	GlyGen The O-GlcNAc Database
161	28510447 33465208 40596516	G49108TO	GlyGen The O-GlcNAc Database
220		G49108TO	GlyGen
222	28510447 33465208 40596516	G49108TO	GlyGen The O-GlcNAc Database
335		G80920RR	GlyGen
566	28510447 33465208 40596516	G49108TO	GlyGen The O-GlcNAc Database
592	23090970 24190977		GlyGen
641		G80920RR	GlyGen
680		G80920RR	GlyGen