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ADAM metallopeptidase domain 28

Summary

Gene Symbol

ADAM28

Organism

Homo sapiens (human)

External Links

NCBI Gene

10863

KEGG Gene ID

PubChem

10863

Alliance of Genome Resources

HGNC:206

Annotation

Keyword

Alternative splicing
Cell membrane
Cleavage on pair of basic residues
Disulfide bond
EGF-like domain
Glycoprotein
Hydrolase
Metal-binding
Metalloprotease
Proteomics identification
Reference proteome
Secreted
Signal
Transmembrane helix
Zinc
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9UKQ2	Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L
A0A384NKT9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
proteolysis	IBA
proteolysis	IEA
spermatogenesis	TAS

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular region	IEA
mitochondrion
plasma membrane	IDA
plasma membrane	IBA
plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
metalloendopeptidase activity	IBA
metalloendopeptidase activity	IEA
protein binding	IPI
metallopeptidase activity	TAS
metallopeptidase activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

binding [inference]

protein binding

signaling receptor binding [inference]

immunoglobulin receptor binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:3910	lung adenocarcinoma	Alliance of Genome Resources
DOID:3908	lung non-small cell carcinoma	Alliance of Genome Resources
DOID:0060075	estrogen-receptor positive breast cancer	Alliance of Genome Resources
DOID:1612	breast cancer	Alliance of Genome Resources
DOID:3008	invasive ductal carcinoma	Alliance of Genome Resources