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aldehyde dehydrogenase family 7, member A1

Summary

Gene Symbol

Aldh7a1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

110695

KEGG Gene ID

PubChem

110695

Alliance of Genome Resources

MGI:108186

Annotation

Keyword

Acetylation
Alternative splicing
Cell membrane
Cytoplasm
Golgi apparatus
Mitochondrion
NAD
Nucleus
Oxidoreductase
Phosphoprotein
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9DBF1	Aldehyde dehydrogenase family 7 member A1 Antiquitin-1 Betaine aldehyde dehydrogenase Delta1-piperideine-6-carboxylate dehydrogenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
obsolete lysine catabolic process
Golgi to endosome transport	ISO
endosome to lysosome transport	ISO
glycine betaine biosynthetic process from choline	IEA
L-lysine catabolic process	ISO

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

modified amino acid metabolic process [inference]

amino-acid betaine metabolic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

modified amino acid biosynthetic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

catabolic process [inference]

amino acid catabolic process [inference]

alpha-amino acid catabolic process

L-amino acid catabolic process [inference]

L-lysine catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

proteinogenic amino acid catabolic process [inference]

L-lysine catabolic process

alpha-amino acid catabolic process

L-amino acid catabolic process [inference]

L-lysine catabolic process

biosynthetic process [inference]

modified amino acid biosynthetic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

choline metabolic process [inference]

glycine betaine biosynthetic process from choline

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

alpha-amino acid catabolic process

L-amino acid catabolic process [inference]

L-lysine catabolic process

proteinogenic amino acid metabolic process [inference]

proteinogenic amino acid catabolic process [inference]

L-lysine catabolic process

alpha-amino acid metabolic process [inference]

L-amino acid metabolic process [inference]

L-amino acid catabolic process [inference]

L-lysine catabolic process

alpha-amino acid catabolic process

L-amino acid catabolic process [inference]

L-lysine catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

proteinogenic amino acid catabolic process [inference]

L-lysine catabolic process

alpha-amino acid catabolic process

L-amino acid catabolic process [inference]

L-lysine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

carboxylic acid catabolic process [inference]

proteinogenic amino acid catabolic process [inference]

L-lysine catabolic process

alpha-amino acid catabolic process

L-amino acid catabolic process [inference]

L-lysine catabolic process

proteinogenic amino acid metabolic process [inference]

proteinogenic amino acid catabolic process [inference]

L-lysine catabolic process

alpha-amino acid metabolic process [inference]

L-amino acid metabolic process [inference]

L-amino acid catabolic process [inference]

L-lysine catabolic process

alpha-amino acid catabolic process

L-amino acid catabolic process [inference]

L-lysine catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

proteinogenic amino acid catabolic process [inference]

L-lysine catabolic process

alpha-amino acid catabolic process

L-amino acid catabolic process [inference]

L-lysine catabolic process

intercellular transport [inference]

vesicle-mediated transport [inference]

endosome to lysosome transport

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport [inference]

Golgi to endosome transport

plasma membrane to endosome transport

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

cytosolic transport [inference]

Golgi to endosome transport

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

energy homeostasis

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

energy homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

intercellular transport [inference]

vesicle-mediated transport [inference]

endosome to lysosome transport

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport [inference]

Golgi to endosome transport

plasma membrane to endosome transport

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

cytosolic transport [inference]

Golgi to endosome transport

establishment of localization in cell [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

cytosolic transport [inference]

Golgi to endosome transport

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport

cytosolic transport [inference]

Golgi to endosome transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane [inference]

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane [inference]

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein localization to plasma membrane [inference]

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane [inference]

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein localization to plasma membrane [inference]

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of intracellular protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of endocytic recycling [inference]

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of vesicle-mediated transport [inference]

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

regulation of endocytic recycling [inference]

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of intracellular protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of endocytic recycling [inference]

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein localization to plasma membrane [inference]

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane [inference]

negative regulation of transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of cellular process [inference]

regulation of programmed cell death [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of ferroptosis [inference]

negative regulation of ferroptosis

negative regulation of cellular process [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane [inference]

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of intracellular protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of endocytic recycling [inference]

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein localization to plasma membrane [inference]

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane [inference]

regulation of vesicle-mediated transport [inference]

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

regulation of endocytic recycling [inference]

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
Golgi membrane	ISS
Golgi membrane	ISO
Golgi membrane	IEA
nucleus	ISS
nucleus	ISO

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

membrane [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
aldehyde dehydrogenase (NAD+) activity	ISS
aldehyde dehydrogenase (NAD+) activity	ISO
aldehyde dehydrogenase (NAD+) activity	IEA
L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity	ISS
L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on NAD(P)H [inference]

oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

oxidoreductase activity, acting on the aldehyde or oxo group of donors [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [inference]

aldehyde dehydrogenase [NAD(P)+] activity [inference]

aldehyde dehydrogenase (NAD+) activity

betaine-aldehyde dehydrogenase (NAD+) activity

L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity

binding [inference]

protein binding [inference]

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dehydrogenase

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
oxidoreductase activity

Displaying **all 5** entries
InterPro
Aldehyde dehydrogenase domain
Aldehyde dehydrogenase, C-terminal
Aldehyde dehydrogenase, N-terminal
Aldehyde dehydrogenase, glutamic acid active site
Aldehyde/histidinol dehydrogenase

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080768	pyridoxine-dependent epilepsy	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements