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Alpha-aminoadipic semialdehyde dehydrogenase

Summary

UniProt ID: Q9DBF1
Gene Symbol: Ald7a1 Aldh7a1
Gene ID: 110695
Organism: Mus musculus (house mouse)

External Links

GlyGen: Q9DBF1
PubChem: Q9DBF1
The O-GlcNAc Database: Q9DBF1
O-GlcNAcAtlas: Q9DBF1
Re-Glyco: Q9DBF1

Annotation

Keyword: Acetylation Alternative splicing Cell membrane Cytoplasm Golgi apparatus Mitochondrion NAD Nucleus Oxidoreductase Phosphoprotein Reference proteome Transit peptide

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
obsolete lysine catabolic process
glycine betaine biosynthetic process from choline
negative regulation of Golgi to plasma membrane protein transport	ISS	GO_REF
negative regulation of Golgi to plasma membrane protein transport	ISO	GO_REF
energy homeostasis	ISS	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

modified amino acid metabolic process [inference]

amino-acid betaine metabolic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

modified amino acid biosynthetic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

biosynthetic process [inference]

modified amino acid biosynthetic process [inference]

amino-acid betaine biosynthetic process [inference]

glycine betaine biosynthetic process [inference]

glycine betaine biosynthetic process from choline

choline metabolic process [inference]

glycine betaine biosynthetic process from choline

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

energy homeostasis

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

energy homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane [inference]

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane [inference]

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein localization to plasma membrane [inference]

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane [inference]

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein localization to plasma membrane [inference]

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of intracellular protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of endocytic recycling [inference]

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of vesicle-mediated transport [inference]

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

regulation of endocytic recycling [inference]

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of intracellular protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of endocytic recycling [inference]

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein localization to plasma membrane [inference]

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane [inference]

negative regulation of transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of cellular process [inference]

regulation of programmed cell death [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of ferroptosis [inference]

negative regulation of ferroptosis

negative regulation of cellular process [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane [inference]

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of intracellular protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of endocytic recycling [inference]

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein localization to plasma membrane [inference]

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane [inference]

regulation of vesicle-mediated transport [inference]

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

regulation of endocytic recycling [inference]

regulation of endosome to plasma membrane protein transport [inference]

negative regulation of endosome to plasma membrane protein transport

negative regulation of endocytic recycling [inference]

negative regulation of endosome to plasma membrane protein transport

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	Reference
Golgi membrane	ISS	GO_REF
Golgi membrane	ISO	GO_REF
Golgi membrane	IEA	GO_REF
nucleus	ISS	GO_REF
nucleus	ISO	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

membrane [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	Reference
aldehyde dehydrogenase (NAD+) activity	ISS	GO_REF
aldehyde dehydrogenase (NAD+) activity	ISO	GO_REF
aldehyde dehydrogenase (NAD+) activity	IEA	GO_REF GO_REF GO_REF GO_REF
L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity	ISS	GO_REF
L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity	ISO	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [inference]

aldehyde dehydrogenase [NAD(P)+] activity [inference]

aldehyde dehydrogenase (NAD+) activity

betaine-aldehyde dehydrogenase (NAD+) activity

L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity

binding [inference]

protein binding [inference]

identical protein binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MWRVPRRLCVQSVKTSKLSGPWSRPAAHMSTLLIHHPQYAWLQDLGLREDNEGVYNGSWGGRGEVITTYCPANNEPIARVRQASLKDYEETIGKAKKAWNIWADIPAPKRGEIVRKIGDAFREKIQLLGRLVSLEMGKILVEGIGEVQEYVDVCDYAAGLSRMIGGPTLPSERPGHALIEMWNPLGLVGIITAFNFPVAVFGWNNAIALITGNVCLWKGAPTTSLVSVAVTKIIAQVLEDNLLPGAICSLVCGGADIGTTMARDERVNLLSFTGSTQVGKEVALMVQERFGKSLLELGGNNAIIAFEDADLSLVVPSVLFAAVGTAGQRCTTVRRLFLHESIHNEVVDRLRSAYSQIRVGNPWDPNILYGPLHTKQAVSMFVRAVEEAKKQGGTVVYGGKVMDHPGNYVEPTIVTGLAHDAPIVHQETFAPILYVFKFQDEEEVFEWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYSTSLPLAQGIKFQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 7** entries
Position	PubMed ID	GlyTouCan ID	Source
56		G39446WN	GlyGen
476	37453647 40021952 40885482	G49108TO	The O-GlcNAc Database
487	37453647 40021952 40885482	G49108TO	The O-GlcNAc Database
488	37453647 40021952 40885482	G49108TO	The O-GlcNAc Database
523	37453647 40021952 40885482	G49108TO	The O-GlcNAc Database
525		G07755XJ	GlyGen
527	37453647 40021952 40885482	G49108TO	GlyGen The O-GlcNAc Database