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Guidelines

MIRAGE

RNA polymerase III subunit A

Summary

Gene Symbol

POLR3A

Organism

Homo sapiens (human)

External Links

NCBI Gene

11128

KEGG Gene ID

PubChem

11128

Alliance of Genome Resources

HGNC:30074

Annotation

Keyword

3D-structure
Acetylation
Antiviral defense
Cytoplasm
DNA-directed RNA polymerase
Disease variant
Innate immunity
Leukodystrophy
Magnesium
Metal-binding
Nucleotidyltransferase
Nucleus
Proteomics identification
Reference proteome
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
O14802	DNA-directed RNA polymerase III largest subunit DNA-directed RNA polymerase III subunit A RNA polymerase III 155 kDa subunit RNA polymerase III subunit C160

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
DNA-templated transcription	NAS
transcription, DNA-templated	NAS
transcription, DNA-templated	IEA
DNA-templated transcription	IEA
transcription by RNA polymerase III	IDA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, DNA-templated

transcription by RNA polymerase III

tRNA transcription by RNA polymerase III

tRNA transcription [inference]

tRNA transcription by RNA polymerase III

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase III promoter

DNA-templated transcription termination [inference]

termination of RNA polymerase III transcription

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, DNA-templated

transcription by RNA polymerase III

tRNA transcription by RNA polymerase III

tRNA transcription [inference]

tRNA transcription by RNA polymerase III

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase III promoter

DNA-templated transcription termination [inference]

termination of RNA polymerase III transcription

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, DNA-templated

transcription by RNA polymerase III

tRNA transcription by RNA polymerase III

tRNA transcription [inference]

tRNA transcription by RNA polymerase III

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase III promoter

DNA-templated transcription termination [inference]

termination of RNA polymerase III transcription

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA transcription [inference]

tRNA transcription by RNA polymerase III

RNA biosynthetic process [inference]

transcription, DNA-templated

transcription by RNA polymerase III

tRNA transcription by RNA polymerase III

tRNA transcription [inference]

tRNA transcription by RNA polymerase III

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase III promoter

DNA-templated transcription termination [inference]

termination of RNA polymerase III transcription

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, DNA-templated

transcription by RNA polymerase III

tRNA transcription by RNA polymerase III

tRNA transcription [inference]

tRNA transcription by RNA polymerase III

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase III promoter

DNA-templated transcription termination [inference]

termination of RNA polymerase III transcription

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, DNA-templated

transcription by RNA polymerase III

tRNA transcription by RNA polymerase III

tRNA transcription [inference]

tRNA transcription by RNA polymerase III

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase III promoter

DNA-templated transcription termination [inference]

termination of RNA polymerase III transcription

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA transcription [inference]

tRNA transcription by RNA polymerase III

RNA biosynthetic process [inference]

transcription, DNA-templated

transcription by RNA polymerase III

tRNA transcription by RNA polymerase III

tRNA transcription [inference]

tRNA transcription by RNA polymerase III

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase III promoter

DNA-templated transcription termination [inference]

termination of RNA polymerase III transcription

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, DNA-templated

transcription by RNA polymerase III

tRNA transcription by RNA polymerase III

tRNA transcription [inference]

tRNA transcription by RNA polymerase III

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase III promoter

DNA-templated transcription termination [inference]

termination of RNA polymerase III transcription

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of type I interferon production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of interferon-beta production [inference]

positive regulation of interferon-beta production

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of type I interferon production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of interferon-beta production [inference]

positive regulation of interferon-beta production

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of type I interferon production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of interferon-beta production [inference]

positive regulation of interferon-beta production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
nucleus	EXP
nucleus	NAS
nucleus	IDA
nucleus	IEA
nucleoplasm	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

RNA polymerase III complex

intracellular protein-containing complex [inference]

RNA polymerase complex [inference]

DNA-directed RNA polymerase complex [inference]

RNA polymerase III complex

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

RNA polymerase complex [inference]

DNA-directed RNA polymerase complex [inference]

RNA polymerase III complex

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
magnesium ion binding	IDA
magnesium ion binding	IEA
DNA binding	IEA
chromatin binding	IEA
DNA-directed RNA polymerase activity	NAS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

RNA polymerase activity [inference]

5'-3' RNA polymerase activity

DNA-directed RNA polymerase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

RNA polymerase activity [inference]

5'-3' RNA polymerase activity

DNA-directed RNA polymerase activity

binding [inference]

nucleic acid binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0081333	Wiedemann-Rautenstrauch syndrome	Alliance of Genome Resources
DOID:0060794	hypomyelinating leukodystrophy 7	Alliance of Genome Resources

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Last updated: April 6, 2026