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DNA-directed RNA polymerase III subunit RPC1

Summary

UniProt ID: O14802
Gene Symbol: POLR3A
Gene ID: 11128
Organism: Homo sapiens (human)

External Links

GlyGen: O14802
PubChem: O14802
The Human Metabolome Database: HMDBP09344
Re-Glyco: O14802

Annotation

Keyword: 3D-structure Acetylation Antiviral defense Cytoplasm DNA-directed RNA polymerase Disease variant Innate immunity Leukodystrophy Magnesium Metal-binding Nucleotidyltransferase Nucleus Proteomics identification Reference proteome Zinc

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
DNA-templated transcription	NAS	PMID
transcription, DNA-templated	NAS	PMID
transcription, DNA-templated	IEA	GO_REF
DNA-templated transcription	IEA	GO_REF
positive regulation of interferon-beta production	IMP	PMID

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, DNA-templated

transcription by RNA polymerase III [inference]

tRNA transcription by RNA polymerase III

tRNA transcription [inference]

tRNA transcription by RNA polymerase III

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, DNA-templated

transcription by RNA polymerase III [inference]

tRNA transcription by RNA polymerase III

tRNA transcription [inference]

tRNA transcription by RNA polymerase III

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, DNA-templated

transcription by RNA polymerase III [inference]

tRNA transcription by RNA polymerase III

tRNA transcription [inference]

tRNA transcription by RNA polymerase III

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA transcription [inference]

tRNA transcription by RNA polymerase III

RNA biosynthetic process [inference]

transcription, DNA-templated

transcription by RNA polymerase III [inference]

tRNA transcription by RNA polymerase III

tRNA transcription [inference]

tRNA transcription by RNA polymerase III

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, DNA-templated

transcription by RNA polymerase III [inference]

tRNA transcription by RNA polymerase III

tRNA transcription [inference]

tRNA transcription by RNA polymerase III

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, DNA-templated

transcription by RNA polymerase III [inference]

tRNA transcription by RNA polymerase III

tRNA transcription [inference]

tRNA transcription by RNA polymerase III

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA transcription [inference]

tRNA transcription by RNA polymerase III

RNA biosynthetic process [inference]

transcription, DNA-templated

transcription by RNA polymerase III [inference]

tRNA transcription by RNA polymerase III

tRNA transcription [inference]

tRNA transcription by RNA polymerase III

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, DNA-templated

transcription by RNA polymerase III [inference]

tRNA transcription by RNA polymerase III

tRNA transcription [inference]

tRNA transcription by RNA polymerase III

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of type I interferon production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of interferon-beta production [inference]

positive regulation of interferon-beta production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of type I interferon production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of interferon-beta production [inference]

positive regulation of interferon-beta production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of type I interferon production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

regulation of interferon-beta production [inference]

positive regulation of interferon-beta production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of type I interferon production [inference]

positive regulation of interferon-beta production

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	Reference
nucleus	EXP	PMID
nucleus	NAS	PMID
nucleus	IDA	PMID
nucleus	IEA	GO_REF
nucleoplasm	TAS	Reactome Reactome Reactome

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

RNA polymerase III complex

intracellular protein-containing complex [inference]

RNA polymerase complex [inference]

DNA-directed RNA polymerase complex [inference]

RNA polymerase III complex

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

RNA polymerase complex [inference]

DNA-directed RNA polymerase complex [inference]

RNA polymerase III complex

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
magnesium ion binding	IDA	PMID
magnesium ion binding	IEA	GO_REF
DNA binding	IEA	GO_REF
chromatin binding	IEA	GO_REF
DNA-directed RNA polymerase activity	NAS	PMID

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

RNA polymerase activity [inference]

5'-3' RNA polymerase activity [inference]

DNA-directed RNA polymerase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

RNA polymerase activity [inference]

5'-3' RNA polymerase activity [inference]

DNA-directed RNA polymerase activity

binding [inference]

nucleic acid binding [inference]

chromatin binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MVKEQFRETDVAKKISHICFGMKSPEEMRQQAHIQVVSKNLYSQDNQHAPLLYGVLDHRMGTSEKDRPCETCGKNLADCLGHYGYIDLELPCFHVGYFRAVIGILQMICKTCCHIMLSQEEKKQFLDYLKRPGLTYLQKRGLKKKISDKCRKKNICHHCGAFNGTVKKCGLLKIIHEKYKTNKKVVDPIVSNFLQSFETAIEHNKEVEPLLGRAQENLNPLVVLNLFKRIPAEDVPLLLMNPEAGKPSDLILTRLLVPPLCIRPSVVSDLKSGTNEDDLTMKLTEIIFLNDVIKKHRISGAKTQMIMEDWDFLQLQCALYINSELSGIPLNMAPKKWTRGFVQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLRIDEVAVPVHVAKILTFPEKVNKANINFLRKLVQNGPEVHPGANFIQQRHTQMKRFLKYGNREKMAQELKYGDIVERHLIDGDVVLFNRQPSLHKLSIMAHLARVKPHRTFRFNECVCTPYNADFDGDEMNLHLPQTEEAKAEALVLMGTKANLVTPRNGEPLIAAIQDFLTGAYLLTLKDTFFDRAKACQIIASILVGKDEKIKVRLPPPTILKPVTLWTGKQIFSVILRPSDDNPVRANLRTKGKQYCGKGEDLCANDSYVTIQNSELMSGSMDKGTLGSGSKNNIFYILLRDWGQNEAADAMSRLARLAPVYLSNRGFSIGIGDVTPGQGLLKAKYELLNAGYKKCDEYIEALNTGKLQQQPGCTAEETLEALILKELSVIRDHAGSACLRELDKSNSPLTMALCGSKGSFINISQMIACVGQQAISGSRVPDGFENRSLPHFEKHSKLPAAKGFVANSFYSGLTPTEFFFHTMAGREGLVDTAVKTAETGYMQRRLVKSLEDLCSQYDLTVRSSTGDIIQFIYGGDGLDPAAMEGKDEPLEFKRVLDNIKAVFPCPSEPALSKNELILTTESIMKKSEFLCCQDSFLQEIKKFIKGVSEKIKKTRDKYGINDNGTTEPRVLYQLDRITPTQVEKFLETCRDKYMRAQMEPGSAVGALCAQSIGEPGTQMTLKTFHFAGVASMNITLGVPRIKEIINASKAISTPIITAQLDKDDDADYARLVKGRIEKTLLGEISEYIEEVFLPDDCFILVKLSLERIRLLRLEVNAETVRYSICTSKLRVKPGDVAVHGEAVVCVTPRENSKSSMYYVLQFLKEDLPKVVVQGIPEVSRAVIHIDEQSGKEKYKLLVEGDNLRAVMATHGVKGTRTTSNNTYEVEKTLGIEAARTTIINEIQYTMVNHGMSIDRRHVMLLSDLMTYKGEVLGITRFGLAKMKESVLMLASFEKTADHLFDAAYFGQKDSVCGVSECIIMGIPMNIGTGLFKLLHKADRDPNPPKRPLIFDTNEFHIPLVT

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
1176				GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 7** entries
Pathway Name	Organism
Cytosolic sensors of pathogen-associated DNA	Homo sapiens
RNA Polymerase III Abortive And Retractive Initiation	Homo sapiens
RNA Polymerase III Chain Elongation	Homo sapiens
RNA Polymerase III Transcription Initiation From Type 1 Promoter	Homo sapiens
RNA Polymerase III Transcription Initiation From Type 2 Promoter	Homo sapiens
RNA Polymerase III Transcription Initiation From Type 3 Promoter	Homo sapiens
RNA Polymerase III Transcription Termination	Homo sapiens

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0081333	Wiedemann-Rautenstrauch syndrome	Alliance of Genome Resources
DOID:0060794	hypomyelinating leukodystrophy 7	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

International Collaboration

Acknowledgements