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RNA Polymerase III Transcription Initiation From Type 2 Promoter

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-76066

PubChem

R-HSA-76066

Description

The type 2 promoters can recruit TFIIIC without the help of TFIIIA because TFIIIC binds directly to the A and B boxes. As for the type 1 promoters, this then allows the binding of Brf1-TFIIIB and RNA polymerase III. Importantly, in the yeast system, once Brf1-TFIIIB has been recruited to type 1 or 2 promoters, TFIIIA and/or TFIIIC can be stripped from the DNA with high salt or heparin treatment. Brf1-TFIIIB remains bound to the DNA and is sufficient to direct multiple rounds of transcription .

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 8** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
A6H8Y1	Transcription factor TFIIIB component B'' homolog	BDP1 KIAA1241 KIAA1689 TFNR	view
O14802	DNA-directed RNA polymerase III subunit RPC1	POLR3A	view
P05423	DNA-directed RNA polymerase III subunit RPC4	BN51 BN51T POLR3D	view
P20226	TATA-box-binding protein	GTF2D1 TBP TF2D TFIID	view
Q12789	General transcription factor 3C polypeptide 1	GTF3C1	view
Q8WUA4	General transcription factor 3C polypeptide 2	GTF3C2 KIAA0011	view
Q9NVU0	DNA-directed RNA polymerase III subunit RPC5	KIAA1452 POLR3E	view
Q9NW08	DNA-directed RNA polymerase III subunit RPC2	POLR3B	view

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