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RNA Polymerase III Transcription Initiation From Type 1 Promoter

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-76061

PubChem

R-HSA-76061

Description

The type 1 promoters recruit TFIIIA, the founding member of the C2H2 zinc finger family of DNA-binding proteins (Engelke et al., 1980; Sakonju et al., 1981). The binding of TFIIIA then allows the binding of TFIIC (Lassar et al., 1983), a complex consisting of five subunits (which differs from the six subunits in S. cerevisiae) in human cells and S. pombe. Once the DNA/TFIIIA/TFIIIC complex is formed, Brf1-TFIIIB joins the complex and this in turn allows the recruitment of RNA polymerase III (Bieker et al., 1985; Setzer and Brown, 1985).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 8** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
A6H8Y1	Transcription factor TFIIIB component B'' homolog	BDP1 KIAA1241 KIAA1689 TFNR	view
O14802	DNA-directed RNA polymerase III subunit RPC1	POLR3A	view
P05423	DNA-directed RNA polymerase III subunit RPC4	BN51 BN51T POLR3D	view
P20226	TATA-box-binding protein	GTF2D1 TBP TF2D TFIID	view
Q12789	General transcription factor 3C polypeptide 1	GTF3C1	view
Q8WUA4	General transcription factor 3C polypeptide 2	GTF3C2 KIAA0011	view
Q9NVU0	DNA-directed RNA polymerase III subunit RPC5	KIAA1452 POLR3E	view
Q9NW08	DNA-directed RNA polymerase III subunit RPC2	POLR3B	view

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