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RNA Polymerase III Transcription Termination

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-73980

PubChem

R-HSA-73980

Description

At the end of the cycle, the elongation complex (EC) must be destabilized to release its transcript and DNA. Analogous to initiation, cis-signals and protein factors are required to mediate EC destabilization and release of the transcript from the grip of the RNA polymerase (RNAP). RNAP III achieves efficient termination despite the apparent simplicity of its cis-acting DNA terminator element, a stretch of five or more T residues on the non-template (NT) strand, which directs termination within this site without need for additional cis-elements or trans-acting factors.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 8** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O00712	Nuclear factor 1 B-type	NFIB	view
O14802	DNA-directed RNA polymerase III subunit RPC1	POLR3A	view
P05423	DNA-directed RNA polymerase III subunit RPC4	BN51 BN51T POLR3D	view
P08651	Nuclear factor 1 C-type	NFI NFIC	view
Q12857	Nuclear factor 1 A-type	KIAA1439 NFIA	view
Q14938	Nuclear factor 1 X-type	NFIX	view
Q9NVU0	DNA-directed RNA polymerase III subunit RPC5	KIAA1452 POLR3E	view
Q9NW08	DNA-directed RNA polymerase III subunit RPC2	POLR3B	view

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