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MIRAGE
cholinergic receptor nicotinic alpha 4 subunit

Summary
Gene Symbol
  • CHRNA4
Organism
Homo sapiens (human)
NCBI Gene
1137
KEGG Gene ID
PubChem
1137
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Cell membrane
  • Disease variant
  • Disulfide bond
  • Epilepsy
  • Glycoprotein
  • Ligand-gated ion channel
  • Palmitate
  • Phosphoprotein
  • Proteomics identification
  • Receptor
  • Reference proteome
  • Signal
  • Synapse
  • Transmembrane helix
Proteins
Displaying all 4 entries
UniProt Protein Name
Q4VAQ3
Q59FV0
P43681
B4DK78
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 40 in total
GO Term Evidence Code PMID
action potential
response to hypoxia
DNA repair
chromatin remodeling
ion transport
GO Hierarchy
Displaying entries 1 - 5 of 15 in total
GO Term Evidence Code PMID
transmembrane signaling receptor activity
ion channel activity
monoatomic ion channel activity
extracellular ligand-gated monoatomic ion channel activity
protein binding
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
acetylcholine receptor subunit
Functional Category
  • E: Amino acid transport and metabolism
  • T: Signal transduction mechanisms
  • X: Mobilome: prophages, transposons
Displaying all 5 entries
Gene Ontology
excitatory postsynaptic potential
extracellular ligand-gated monoatomic ion channel activity
monoatomic ion channel activity
monoatomic ion transport
regulation of postsynaptic membrane potential
Displaying all 8 entries
InterPro
Neuronal acetylcholine receptor
Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Neurotransmitter-gated ion-channel ligand-binding domain
Neurotransmitter-gated ion-channel transmembrane domain superfamily
Neurotransmitter-gated ion-channel transmembrane domain
Neurotransmitter-gated ion-channel, conserved site
Neurotransmitter-gated ion-channel
Nicotinic acetylcholine receptor
Disease
Disease Ontology
Displaying all 2 entries
DO ID Disease Name Source
DOID:0060682 autosomal dominant nocturnal frontal lobe epilepsy 1
DOID:0050742 nicotine dependence
Ortholog
Displaying all 7 entries
Species Gene ID Alliance of Genome Resources
11438 MGI:87888
25590 RGD:2346
172105 WB:WBGene00006774
172150 WB:WBGene00006797
172703 WB:WBGene00006765
42919 FB:FBgn0000039
42920 FB:FBgn0004118
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026