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MIRAGE
Neuronal acetylcholine receptor subunit alpha-4
Summary
- UniProt ID
- P43681
- Gene Symbol
- CHRNA4 NACRA4
- Gene ID
- 1137
- Organism
- Homo sapiens (human)
External Links
- PubChem
- P43681
- The Human Metabolome Database
- HMDBP12050
- Re-Glyco
- P43681
Annotation
- Keyword
- 3D-structure Alternative splicing Cell membrane Disease variant Disulfide bond Epilepsy Glycoprotein Ligand-gated ion channel Palmitate Phosphoprotein Proteomics identification Receptor Reference proteome Signal Synapse Transmembrane helix
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| action potential | ||
| response to hypoxia | ||
| DNA repair | ||
| ion transport | ||
| monoatomic ion transport |
| GO Term | Evidence Code | Reference |
|---|---|---|
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane | ||
| acetylcholine-gated channel complex |
GO Hierarchy
| GO Term | Evidence Code | Reference |
|---|---|---|
| ligand-gated monoatomic ion channel activity | ||
| acetylcholine receptor activity | ||
| acetylcholine receptor activity | ||
| acetylcholine-gated monoatomic cation-selective channel activity | ||
| acetylcholine-gated monoatomic cation-selective channel activity |
GO Hierarchy
Sequence
MELGGPGAPRLLPPLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPATSGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHGTQAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPRDDAAPEADGQAAGALASRNTHSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Highly calcium permeable nicotinic acetylcholine receptors | Homo sapiens |
| Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | Homo sapiens |
| Highly sodium permeable postsynaptic acetylcholine nicotinic receptors | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050742 | nicotine dependence | |
| DOID:0060682 | autosomal dominant nocturnal frontal lobe epilepsy 1 |
