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BUD23 rRNA methyltransferase and ribosome maturation factor

Summary

Gene Symbol

BUD23

Organism

Homo sapiens (human)

External Links

NCBI Gene

114049

PubChem

114049

Alliance of Genome Resources

HGNC:16405

JoGo

BUD23

TogoVar

BUD23

Annotation

Keyword

3D-structure
Alternative splicing
Chromatin regulator
Cytoplasm
Methyltransferase
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Ribosome biogenesis
S-adenosyl-L-methionine
Transcription regulation
Ubl conjugation
Williams-Beuren syndrome
rRNA processing

Proteins

Displaying 1 entry
UniProt	Protein Name
O43709	Bud site selection protein 23 homolog Metastasis-related methyltransferase 1 Williams-Beuren syndrome chromosomal region 22 protein rRNA methyltransferase and ribosome maturation factor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
chromatin organization
rRNA processing	IEA
rRNA (guanine-N7)-methylation	NAS	25851604
rRNA (guanine-N7)-methylation	IMP	25851604
rRNA (guanine-N7)-methylation	IBA	http://purl.obolibrary.org/obo/go/references/0000033

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

methylation [inference]

macromolecule methylation [inference]

RNA methylation [inference]

rRNA methylation [inference]

rRNA base methylation [inference]

rRNA (guanine-N7)-methylation

RNA (guanine-N7)-methylation [inference]

rRNA (guanine-N7)-methylation

macromolecule metabolic process [inference]

macromolecule modification [inference]

RNA modification [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation [inference]

rRNA (guanine-N7)-methylation

RNA methylation [inference]

rRNA methylation [inference]

rRNA base methylation [inference]

rRNA (guanine-N7)-methylation

RNA (guanine-N7)-methylation [inference]

rRNA (guanine-N7)-methylation

macromolecule methylation [inference]

RNA methylation [inference]

rRNA methylation [inference]

rRNA base methylation [inference]

rRNA (guanine-N7)-methylation

RNA (guanine-N7)-methylation [inference]

rRNA (guanine-N7)-methylation

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA modification [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation [inference]

rRNA (guanine-N7)-methylation

RNA methylation [inference]

rRNA methylation [inference]

rRNA base methylation [inference]

rRNA (guanine-N7)-methylation

RNA (guanine-N7)-methylation [inference]

rRNA (guanine-N7)-methylation

rRNA metabolic process [inference]

rRNA processing

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation [inference]

rRNA (guanine-N7)-methylation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA modification [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation [inference]

rRNA (guanine-N7)-methylation

RNA methylation [inference]

rRNA methylation [inference]

rRNA base methylation [inference]

rRNA (guanine-N7)-methylation

RNA (guanine-N7)-methylation [inference]

rRNA (guanine-N7)-methylation

rRNA metabolic process [inference]

rRNA processing

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation [inference]

rRNA (guanine-N7)-methylation

RNA processing [inference]

rRNA processing

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation [inference]

rRNA (guanine-N7)-methylation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

chromatin organization

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of rRNA processing [inference]

positive regulation of rRNA processing

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of rRNA processing [inference]

positive regulation of rRNA processing

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

regulation of rRNA processing [inference]

positive regulation of rRNA processing

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

regulation of rRNA processing [inference]

positive regulation of rRNA processing

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

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GO Term	Evidence Code	PMID
nucleus	EXP	24086612 24488492
nucleus	IDA	26214185 34948388
nucleus	IEA	http://purl.obolibrary.org/obo/go/references/0000044
nucleoplasm	TAS	https://reactome.org/content/detail/R-HSA-6790982
nucleoplasm	IDA	25851604 http://purl.obolibrary.org/obo/go/references/0000052

GO Hierarchy

cellular component

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

nucleolus

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
RNA binding	HDA	22681889
protein binding	IPI	25851604 28514442 32296183 33961781 34948388 40205054
methyltransferase activity	NAS	11124703
S-adenosylmethionine-dependent methyltransferase activity	IEA
rRNA (guanine) methyltransferase activity	IMP	25851604

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring one-carbon groups [inference]

methyltransferase activity

RNA methyltransferase activity [inference]

rRNA methyltransferase activity [inference]

rRNA (guanine) methyltransferase activity

S-adenosylmethionine-dependent methyltransferase activity

rRNA methyltransferase activity [inference]

rRNA (guanine) methyltransferase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

RNA methyltransferase activity [inference]

rRNA methyltransferase activity [inference]

rRNA (guanine) methyltransferase activity

catalytic activity, acting on a rRNA [inference]

rRNA methyltransferase activity [inference]

rRNA (guanine) methyltransferase activity

binding [inference]

nucleic acid binding [inference]

RNA binding

protein binding

protein dimerization activity [inference]

protein heterodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

methyltransferase

Functional Category

H: Coenzyme transport and metabolism
J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair

Displaying **all 5** entries
Gene Ontology
S-adenosylmethionine-dependent methyltransferase activity
methylation
rRNA (guanine) methyltransferase activity
rRNA (guanine-N7)-methylation
transferase activity

Displaying **all 4** entries
InterPro
18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23, C-terminal
18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23-like
Methyltransferase type 11
S-adenosyl-L-methionine-dependent methyltransferase superfamily