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18S rRNA (guanine-N(7))-methyltransferase

Summary

UniProt ID: O43709
Gene Symbol: BUD23 HUSSY-03 MERM1 PP3381 WBSCR22
Gene ID: 114049
Organism: Homo sapiens (human)

External Links

PubChem: O43709
The Human Metabolome Database: HMDBP12007
The O-GlcNAc Database: O43709
Re-Glyco: O43709

Annotation

Keyword: 3D-structure Alternative splicing Chromatin regulator Cytoplasm Methyltransferase Nucleus Phosphoprotein Proteomics identification Reference proteome Ribosome biogenesis S-adenosyl-L-methionine Transcription regulation Ubl conjugation Williams-Beuren syndrome rRNA processing

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
chromatin organization
rRNA (guanine-N7)-methylation	NAS	PMID
rRNA (guanine-N7)-methylation	IMP	PMID
rRNA (guanine-N7)-methylation	IBA	GO_REF
rRNA (guanine-N7)-methylation	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

methylation [inference]

macromolecule methylation [inference]

RNA methylation [inference]

rRNA methylation [inference]

rRNA base methylation [inference]

rRNA (guanine-N7)-methylation

RNA (guanine-N7)-methylation [inference]

rRNA (guanine-N7)-methylation

macromolecule metabolic process [inference]

macromolecule modification [inference]

RNA modification [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation [inference]

rRNA (guanine-N7)-methylation

RNA methylation [inference]

rRNA methylation [inference]

rRNA base methylation [inference]

rRNA (guanine-N7)-methylation

RNA (guanine-N7)-methylation [inference]

rRNA (guanine-N7)-methylation

macromolecule methylation [inference]

RNA methylation [inference]

rRNA methylation [inference]

rRNA base methylation [inference]

rRNA (guanine-N7)-methylation

RNA (guanine-N7)-methylation [inference]

rRNA (guanine-N7)-methylation

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA modification [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation [inference]

rRNA (guanine-N7)-methylation

RNA methylation [inference]

rRNA methylation [inference]

rRNA base methylation [inference]

rRNA (guanine-N7)-methylation

RNA (guanine-N7)-methylation [inference]

rRNA (guanine-N7)-methylation

rRNA metabolic process [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation [inference]

rRNA (guanine-N7)-methylation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA modification [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation [inference]

rRNA (guanine-N7)-methylation

RNA methylation [inference]

rRNA methylation [inference]

rRNA base methylation [inference]

rRNA (guanine-N7)-methylation

RNA (guanine-N7)-methylation [inference]

rRNA (guanine-N7)-methylation

rRNA metabolic process [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation [inference]

rRNA (guanine-N7)-methylation

RNA processing [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA methylation [inference]

rRNA base methylation [inference]

rRNA (guanine-N7)-methylation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

chromatin organization

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of rRNA processing [inference]

positive regulation of rRNA processing

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of rRNA processing [inference]

positive regulation of rRNA processing

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

regulation of rRNA processing [inference]

positive regulation of rRNA processing

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

regulation of rRNA processing [inference]

positive regulation of rRNA processing

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of rRNA processing

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GO Term	Evidence Code	Reference
nucleus	EXP	PMID PMID
nucleus	IDA	PMID PMID
nucleus	IEA	GO_REF
nucleoplasm	TAS	Reactome
nucleoplasm	IDA	PMID GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

nucleolus

perinuclear region of cytoplasm

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GO Term	Evidence Code	Reference
RNA binding	HDA	PMID
methyltransferase activity	NAS	PMID
rRNA (guanine) methyltransferase activity	IMP	PMID
rRNA (guanine) methyltransferase activity	IBA	GO_REF
rRNA (guanine) methyltransferase activity	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring one-carbon groups [inference]

methyltransferase activity

RNA methyltransferase activity [inference]

rRNA methyltransferase activity [inference]

rRNA (guanine) methyltransferase activity

S-adenosylmethionine-dependent methyltransferase activity [inference]

rRNA methyltransferase activity [inference]

rRNA (guanine) methyltransferase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

RNA methyltransferase activity [inference]

rRNA methyltransferase activity [inference]

rRNA (guanine) methyltransferase activity

catalytic activity, acting on a rRNA [inference]

rRNA methyltransferase activity [inference]

rRNA (guanine) methyltransferase activity

binding [inference]

nucleic acid binding [inference]

RNA binding

protein binding [inference]

protein dimerization activity [inference]

protein heterodimerization activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MASRGRRPEHGGPPELFYDETEARKYVRNSRMIDIQTRMAGRALELLYLPENKPCYLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDREIEGDLLLGDMGQGIPFKPGTFDGCISISAVQWLCNANKKSENPAKRLYCFFASLFSVLVRGSRAVLQLYPENSEQLELITTQATKAGFSGGMVVDYPNSAKAKKFYLCLFSGPSTFIPEGLSENQDEVEPRESVFTNERFPLRMSRRGMVRKSRAWVLEKKERHRRQGREVRPDTQYTGRKRKPRF

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
194		28510447 33214551 34019948 38253038 40596516	G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Major pathway of rRNA processing in the nucleolus and cytosol	Homo sapiens
rRNA modification in the nucleus and cytosol	Homo sapiens

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1928	Williams-Beuren syndrome	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements