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TIMP metallopeptidase inhibitor 1

Summary

Gene Symbol

Timp1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

116510

PubChem

116510

Alliance of Genome Resources

RGD:621675

Annotation

Keyword

Direct protein sequencing
Disulfide bond
Glycoprotein
Growth factor
Metal-binding
Metalloprotease inhibitor
Phosphoprotein
Reference proteome
Secreted
Signal
Steroidogenesis
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6JZR1	Tissue inhibitor of metalloproteinases 1
P30120	Tissue inhibitor of metalloproteinases 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
connective tissue replacement involved in inflammatory response wound healing	ISO
steroid biosynthetic process	IEA
signal transduction	IEA
positive regulation of cell population proliferation	ISS
positive regulation of cell population proliferation	ISO

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

cellular process [inference]

signal transduction

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide

cellular response to oxygen-containing compound [inference]

cellular response to peptide

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-A

multicellular organismal process [inference]

tissue remodeling [inference]

connective tissue replacement [inference]

connective tissue replacement involved in inflammatory response wound healing

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

cartilage development

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

response to UV [inference]

cellular response to UV [inference]

cellular response to UV-A

response to UV-A [inference]

cellular response to UV-A

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-A

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-A

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-A

response to endogenous stimulus [inference]

response to hormone

response to peptide hormone

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide

response to chemical [inference]

response to organic substance [inference]

response to hormone

response to peptide hormone

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide

response to peptide [inference]

response to cytokine

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide

cellular response to oxygen-containing compound [inference]

cellular response to peptide

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide

response to peptide [inference]

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide

response to oxygen-containing compound [inference]

response to peptide [inference]

cellular response to oxygen-containing compound [inference]

cellular response to peptide

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide

cellular response to oxygen-containing compound [inference]

cellular response to peptide

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-A

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of cellular catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of cellular catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

regulation of metallopeptidase activity [inference]

negative regulation of metallopeptidase activity

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

regulation of metallopeptidase activity [inference]

negative regulation of metallopeptidase activity

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

regulation of metallopeptidase activity [inference]

negative regulation of metallopeptidase activity

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of integrin-mediated signaling pathway

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of trophoblast cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration [inference]

negative regulation of trophoblast cell migration

regulation of trophoblast cell migration [inference]

negative regulation of trophoblast cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of trophoblast cell migration

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of trophoblast cell migration

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of trophoblast cell migration

negative regulation of multicellular organismal process [inference]

negative regulation of trophoblast cell migration

negative regulation of reproductive process [inference]

negative regulation of trophoblast cell migration

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of integrin-mediated signaling pathway

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of integrin-mediated signaling pathway

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of cellular catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of trophoblast cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration [inference]

negative regulation of trophoblast cell migration

regulation of trophoblast cell migration [inference]

negative regulation of trophoblast cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of trophoblast cell migration

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of trophoblast cell migration

regulation of reproductive process [inference]

regulation of trophoblast cell migration [inference]

negative regulation of trophoblast cell migration

negative regulation of reproductive process [inference]

negative regulation of trophoblast cell migration

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

regulation of catalytic activity [inference]

negative regulation of catalytic activity

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

regulation of metallopeptidase activity [inference]

negative regulation of metallopeptidase activity

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
basement membrane	ISO
basement membrane	IDA	9579471
extracellular space	ISS
extracellular space	ISO
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix [inference]

basement membrane

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
protease binding	IPI	21846328
cytokine activity	ISS
cytokine activity	ISO
protein binding	IPI	28659595
growth factor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

receptor ligand activity [inference]

enzyme binding [inference]

protease binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity

endopeptidase inhibitor activity [inference]

metalloendopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity

endopeptidase inhibitor activity [inference]

metalloendopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

metalloendopeptidase inhibitor activity

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity

endopeptidase inhibitor activity [inference]

metalloendopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Metalloproteinase inhibitor 3

Functional Category

E: Amino acid transport and metabolism
K: Transcription
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 7** entries
Gene Ontology
metal ion binding
metalloendopeptidase inhibitor activity
negative regulation of membrane protein ectodomain proteolysis
peptidase inhibitor activity
protease binding
response to cytokine
response to hormone

Displaying **all 4** entries
InterPro
Netrin domain
Protease inhibitor I35 (TIMP)
Proteinase inhibitor I35b (TIMP), C-terminal
Tissue inhibitor of metalloproteinases-like, OB-fold

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
basement membrane	PMID:9579471

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:90	degenerative disc disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 48 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	7076	HGNC:11820	HUMAN100414
Drosophila melanogaster	7078	FB:FBgn0025879
Mus musculus	21857	HGNC:11820	MOUSE66667
Drosophila melanogaster	21859	FB:FBgn0025879
Homo sapiens	116510	HGNC:11820
Homo sapiens	179197	HGNC:11820
Drosophila melanogaster	179199	FB:FBgn0025879
Sus scrofa	396862		PIGXX37249
Macaca mulatta	574348		MACMU47679
Equus caballus	100034220		HORSE44850

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

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Acknowledgements