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STEAP family member 4

Summary

Gene Symbol

Steap4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

117167

KEGG Gene ID

PubChem

117167

Alliance of Genome Resources

MGI:1923560

Annotation

Keyword

Cell membrane
Copper
Endosome
FAD
Golgi apparatus
Heme
Iron transport
NADP
Oxidoreductase
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q923B6	Dudulin-4 Six-transmembrane epithelial antigen of prostate 4 Tumor necrosis factor-alpha-induced adipose-related protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
copper ion import	IDA
copper ion import	IBA
copper ion import	IEA
iron import into cell	IDA
iron import into cell	IEA

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

iron ion transmembrane transport

iron ion import across cell outer membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis [inference]

iron import into cell

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis [inference]

iron import into cell

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis [inference]

iron import into cell

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis [inference]

iron import into cell

inorganic ion homeostasis [inference]

intracellular iron ion homeostasis [inference]

iron import into cell

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

copper ion transport [inference]

copper ion import

iron ion transport [inference]

iron import into cell

iron ion transmembrane transport

iron ion import across cell outer membrane

monoatomic cation transmembrane transport [inference]

iron ion transmembrane transport

iron ion import across cell outer membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

iron ion transmembrane transport

iron ion import across cell outer membrane

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

iron ion transmembrane transport

iron ion import across cell outer membrane

establishment of localization in cell [inference]

iron import into cell

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
Golgi membrane	ISO
Golgi membrane	IEA
nucleoplasm	ISO
endosome	IDA
endosome	IBA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

nucleoplasm

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

early endosome membrane

bounding membrane of organelle [inference]

Golgi membrane

endosome membrane [inference]

early endosome membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Displaying entries **11 - 14** of 14 in total

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GO Term	Evidence Code	PMID
ferric-chelate reductase (NADPH) activity	IBA
ferric-chelate reductase (NADPH) activity	IEA
FAD binding	ISO
FAD binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on metal ions [inference]

ferric-chelate reductase activity [inference]

ferric-chelate reductase (NADPH) activity

oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor [inference]

binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

cation binding [inference]

metal ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

tetrapyrrole binding [inference]

heme binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

electron transfer activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Metalloreductase STEAP4

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
copper ion import
cupric reductase activity
ferric-chelate reductase (NADPH) activity

Displaying **all 3** entries
InterPro
Ferric reductase transmembrane component-like domain
NAD(P)-binding domain superfamily
Pyrroline-5-carboxylate reductase, catalytic, N-terminal

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Homo sapiens	79689	HGNC:21923

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Last updated: April 6, 2026

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Acknowledgements