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arylsulfatase A

Summary

Gene Symbol

Arsa

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11883

PubChem

11883

Alliance of Genome Resources

MGI:88077

Annotation

Keyword

Calcium
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Hydrolase
Lipid metabolism
Lysosome
Metal-binding
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P50428	Cerebroside-sulfatase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
lipid metabolic process	IEA
autophagy	ISO
autophagy	IEA
binding of sperm to zona pellucida	IMP	12080020
response to nutrient	ISO

GO Hierarchy

biological process

cellular process [inference]

cell recognition [inference]

cell-cell recognition [inference]

sperm-egg recognition [inference]

binding of sperm to zona pellucida

metabolic process [inference]

catabolic process [inference]

autophagy

primary metabolic process [inference]

lipid metabolic process

process utilizing autophagic mechanism [inference]

autophagy

response to stimulus [inference]

response to abiotic stimulus [inference]

response to pH

response to endogenous stimulus [inference]

response to hormone [inference]

response to estrogen

response to nutrient levels [inference]

response to nutrient

response to chemical [inference]

response to nutrient

response to hormone [inference]

response to estrogen

response to methylmercury

response to oxygen-containing compound [inference]

response to alcohol [inference]

response to ethanol

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GO Term	Evidence Code	PMID
acrosomal vesicle	ISO
acrosomal vesicle	IEA
obsolete extracellular space	ISO
obsolete extracellular space	HDA	24006456
lysosome	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

extrinsic component of membrane [inference]

extrinsic component of plasma membrane [inference]

extrinsic component of external side of plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

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GO Term	Evidence Code	PMID
arylsulfatase activity	ISO
arylsulfatase activity	IBA
arylsulfatase activity	IEA
cerebroside-sulfatase activity	IEA
calcium ion binding	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

sulfuric ester hydrolase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

arylsulfatase I

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
hydrolase activity
sulfuric ester hydrolase activity

Displaying **all 3** entries
InterPro
Alkaline-phosphatase-like, core domain superfamily
Sulfatase, N-terminal
Sulfatase, conserved site

Rhea

RHEA:21300

H₂O + N-acyl-1-β-D-(3-O-sulfo)-galactosyl-sphing-4-enine

H⁺ + sulfate + a β-D-galactosyl-(1↔1ʼ)-N-acylsphing-4-enine

Enzyme

3.1.6.8

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:10581	metachromatic leukodystrophy	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002038
Gene Name: arylsulfatase A

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements