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tripeptidyl peptidase I

Summary

Gene Symbol

Tpp1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12751

KEGG Gene ID

PubChem

12751

Alliance of Genome Resources

MGI:1336194

Annotation

Keyword

Autocatalytic cleavage
Calcium
Disulfide bond
Glycoprotein
Lysosome
Metal-binding
Reference proteome
Serine protease
Signal
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
O89023	Lysosomal pepstatin-insensitive protease Tripeptidyl aminopeptidase Tripeptidyl-peptidase I

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
proteolysis	ISS
proteolysis	ISO
proteolysis	IBA
proteolysis	IEA
lysosome organization	IMP

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

peptide catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

protein metabolic process [inference]

proteolysis

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein catabolic process

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

lytic vacuole organization [inference]

lysosome organization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

neuromuscular process [inference]

neuromuscular process controlling balance

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

bone resorption

developmental process [inference]

anatomical structure development [inference]

system development [inference]

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

bone resorption

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromosome, telomeric region

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
mitochondrion	HDA
lysosome	ISS
lysosome	ISO
lysosome	IDA
lysosome	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

membrane microdomain [inference]

membrane raft

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

pigment granule [inference]

melanosome

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

pigment granule [inference]

melanosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

pigment granule [inference]

melanosome

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
endopeptidase activity	ISS
endopeptidase activity	ISO
endopeptidase activity	IBA
endopeptidase activity	IEA
serine-type endopeptidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

exopeptidase activity [inference]

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

exopeptidase activity [inference]

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

binding [inference]

protein binding

lipid binding [inference]

phospholipid binding [inference]

lysophosphatidic acid binding

glycolipid binding [inference]

sulfatide binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

lysophosphatidic acid binding

cation binding [inference]

metal ion binding

peptide binding

carbohydrate derivative binding [inference]

lysophosphatidic acid binding

glycolipid binding [inference]

sulfatide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Tripeptidyl peptidase a

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying **all 6** entries
Gene Ontology
hydrolase activity
metal ion binding
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity
tripeptidyl-peptidase activity

Displaying **all 4** entries
InterPro
Peptidase S53, activation domain
Peptidase S8/S53 domain superfamily
Peptidase S8/S53 domain
Sedolisin domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110726	neuronal ceroid lipofuscinosis 2	Alliance of Genome Resources

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	83534	RGD:621296
Homo sapiens	1200	HGNC:2073
Danio rerio	798347	ZFIN:ZDB-GENE-030131-6654

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements