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collagen type IV alpha 1 chain

Summary

Gene Symbol

COL4A1

Organism

Homo sapiens (human)

External Links

NCBI Gene

1282

KEGG Gene ID

PubChem

1282

Alliance of Genome Resources

HGNC:2202

Annotation

Keyword

3D-structure
Alternative splicing
Angiogenesis
Basement membrane
Collagen
Direct protein sequencing
Disease variant
Disulfide bond
Extracellular matrix
Glycoprotein
Hydroxylation
Proteomics identification
Reference proteome
Repeat
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P02462
A5PKV2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
branching involved in blood vessel morphogenesis	IMP
brain development	IMP
neuromuscular junction development
extracellular matrix organization	IBA
collagen fibril organization	NAS

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

collagen-activated tyrosine kinase receptor signaling pathway

collagen-activated signaling pathway [inference]

collagen-activated tyrosine kinase receptor signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

synapse organization [inference]

neuromuscular junction development

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

multicellular organismal process [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in blood vessel morphogenesis

developmental process [inference]

anatomical structure morphogenesis [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in blood vessel morphogenesis

tube morphogenesis [inference]

blood vessel morphogenesis

retinal blood vessel morphogenesis

branching morphogenesis of an epithelial tube [inference]

branching involved in blood vessel morphogenesis

epithelial tube morphogenesis [inference]

renal tubule morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

epithelial tube morphogenesis [inference]

renal tubule morphogenesis

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in blood vessel morphogenesis

retina vasculature morphogenesis in camera-type eye [inference]

retinal blood vessel morphogenesis

anatomical structure development [inference]

animal organ development [inference]

brain development

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

response to stimulus [inference]

response to chemical [inference]

response to acid chemical [inference]

response to amino acid [inference]

cellular response to amino acid stimulus

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

collagen-activated tyrosine kinase receptor signaling pathway

collagen-activated signaling pathway [inference]

collagen-activated tyrosine kinase receptor signaling pathway

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
extracellular region	NAS
extracellular region	TAS
extracellular region	IEA
collagen trimer	IEA
collagen type IV trimer	IMP

GO Hierarchy

cellular component

protein-containing complex [inference]

collagen trimer

network-forming collagen trimer [inference]

collagen type IV trimer

extracellular protein-containing complex [inference]

network-forming collagen trimer [inference]

collagen type IV trimer

cellular anatomical structure [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

basement membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
extracellular matrix structural constituent	IMP
extracellular matrix structural constituent	IEA
protein binding	IPI
extracellular matrix structural constituent conferring tensile strength	RCA
extracellular matrix structural constituent conferring tensile strength	IMP

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

extracellular matrix structural constituent conferring tensile strength

binding [inference]

protein binding

growth factor binding [inference]

platelet-derived growth factor binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Collagen alpha-1(IV) chain

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism

Displaying **all 3** entries
Gene Ontology
extracellular matrix organization
extracellular matrix structural constituent conferring tensile strength
extracellular matrix structural constituent

Displaying **all 4** entries
InterPro
C-type lectin fold
Collagen IV, non-collagenous domain superfamily
Collagen IV, non-collagenous
Collagen triple helix repeat

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0111547	retinal arterial tortuosity	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:0090125	brain small vessel disease 1	Alliance of Genome Resources
DOID:13223	uterine fibroid	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements