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Collagen alpha-1(IV) chain

Summary

UniProt ID: P02462
Gene Symbol: COL4A1
Gene ID: 1282
Organism: Homo sapiens (human)

External Links

GlyGen: P02462
PubChem: P02462
The O-GlcNAc Database: P02462
RaftProt: P02462
Re-Glyco: P02462

Annotation

Keyword: 3D-structure Alternative splicing Angiogenesis Basement membrane Collagen Direct protein sequencing Disease variant Disulfide bond Glycoprotein Hydroxylation Proteomics identification Reference proteome Repeat Signal

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
branching involved in blood vessel morphogenesis	IMP	PMID
brain development	IMP	PMID
neuromuscular junction development
collagen fibril organization	NAS	PMID
epithelial cell differentiation	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

collagen-activated tyrosine kinase receptor signaling pathway

collagen-activated signaling pathway [inference]

collagen-activated tyrosine kinase receptor signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

synapse organization [inference]

neuromuscular junction development

extracellular structure organization [inference]

extracellular matrix organization [inference]

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

multicellular organismal process [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in blood vessel morphogenesis

developmental process [inference]

anatomical structure morphogenesis [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in blood vessel morphogenesis

tube morphogenesis [inference]

blood vessel morphogenesis

retinal blood vessel morphogenesis

branching morphogenesis of an epithelial tube [inference]

branching involved in blood vessel morphogenesis

epithelial tube morphogenesis [inference]

renal tubule morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

epithelial tube morphogenesis [inference]

renal tubule morphogenesis

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

branching involved in blood vessel morphogenesis

retina vasculature morphogenesis in camera-type eye [inference]

retinal blood vessel morphogenesis

anatomical structure development [inference]

animal organ development [inference]

brain development

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

response to stimulus [inference]

response to chemical [inference]

response to acid chemical [inference]

response to amino acid [inference]

cellular response to amino acid stimulus

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

collagen-activated tyrosine kinase receptor signaling pathway

collagen-activated signaling pathway [inference]

collagen-activated tyrosine kinase receptor signaling pathway

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GO Term	Evidence Code	Reference
extracellular region	NAS	PMID
extracellular region	TAS	Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome
extracellular region	IEA	GO_REF
collagen type IV trimer	IMP	PMID
collagen type IV trimer	IBA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

collagen trimer [inference]

network-forming collagen trimer [inference]

collagen type IV trimer

extracellular protein-containing complex [inference]

network-forming collagen trimer [inference]

collagen type IV trimer

cellular anatomical structure [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

basement membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

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GO Term	Evidence Code	Reference
extracellular matrix structural constituent	IMP	PMID
extracellular matrix structural constituent	IEA	GO_REF
extracellular matrix structural constituent conferring tensile strength	RCA	PMID PMID PMID PMID PMID PMID
extracellular matrix structural constituent conferring tensile strength	IMP	PMID
extracellular matrix structural constituent conferring tensile strength	IBA	GO_REF

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

extracellular matrix structural constituent conferring tensile strength

binding [inference]

protein binding [inference]

growth factor binding [inference]

platelet-derived growth factor binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGPRLSVWLLLLPAALLLHEEHSRAAAKGGCAGSGCGKCDCHGVKGQKGERGLPGLQGVIGFPGMQGPEGPQGPPGQKGDTGEPGLPGTKGTRGPPGASGYPGNPGLPGIPGQDGPPGPPGIPGCNGTKGERGPLGPPGLPGFAGNPGPPGLPGMKGDPGEILGHVPGMLLKGERGFPGIPGTPGPPGLPGLQGPVGPPGFTGPPGPPGPPGPPGEKGQMGLSFQGPKGDKGDQGVSGPPGVPGQAQVQEKGDFATKGEKGQKGEPGFQGMPGVGEKGEPGKPGPRGKPGKDGDKGEKGSPGFPGEPGYPGLIGRQGPQGEKGEAGPPGPPGIVIGTGPLGEKGERGYPGTPGPRGEPGPKGFPGLPGQPGPPGLPVPGQAGAPGFPGERGEKGDRGFPGTSLPGPSGRDGLPGPPGSPGPPGQPGYTNGIVECQPGPPGDQGPPGIPGQPGFIGEIGEKGQKGESCLICDIDGYRGPPGPQGPPGEIGFPGQPGAKGDRGLPGRDGVAGVPGPQGTPGLIGQPGAKGEPGEFYFDLRLKGDKGDPGFPGQPGMPGRAGSPGRDGHPGLPGPKGSPGSVGLKGERGPPGGVGFPGSRGDTGPPGPPGYGPAGPIGDKGQAGFPGGPGSPGLPGPKGEPGKIVPLPGPPGAEGLPGSPGFPGPQGDRGFPGTPGRPGLPGEKGAVGQPGIGFPGPPGPKGVDGLPGDMGPPGTPGRPGFNGLPGNPGVQGQKGEPGVGLPGLKGLPGLPGIPGTPGEKGSIGVPGVPGEHGAIGPPGLQGIRGEPGPPGLPGSVGSPGVPGIGPPGARGPPGGQGPPGLSGPPGIKGEKGFPGFPGLDMPGPKGDKGAQGLPGITGQSGLPGLPGQQGAPGIPGFPGSKGEMGVMGTPGQPGSPGPVGAPGLPGEKGDHGFPGSSGPRGDPGLKGDKGDVGLPGKPGSMDKVDMGSMKGQKGDQGEKGQIGPIGEKGSRGDPGTPGVPGKDGQAGQPGQPGPKGDPGISGTPGAPGLPGPKGSVGGMGLPGTPGEKGVPGIPGPQGSPGLPGDKGAKGEKGQAGPPGIGIPGLRGEKGDQGIAGFPGSPGEKGEKGSIGIPGMPGSPGLKGSPGSVGYPGSPGLPGEKGDKGLPGLDGIPGVKGEAGLPGTPGPTGPAGQKGEPGSDGIPGSAGEKGEPGLPGRGFPGFPGAKGDKGSKGEVGFPGLAGSPGIPGSKGEQGFMGPPGPQGQPGLPGSPGHATEGPKGDRGPQGQPGLPGLPGPMGPPGLPGIDGVKGDKGNPGWPGAPGVPGPKGDPGFQGMPGIGGSPGITGSKGDMGPPGVPGFQGPKGLPGLQGIKGDQGDQGVPGAKGLPGPPGPPGPYDIIKGEPGLPGPEGPPGLKGLQGLPGPKGQQGVTGLVGIPGPPGIPGFDGAPGQKGEMGPAGPTGPRGFPGPPGPDGLPGSMGPPGTPSVDHGFLVTRHSQTIDDPQCPSGTKILYHGYSLLYVQGNERAHGQDLGTAGSCLRKFSTMPFLFCNINNVCNFASRNDYSYWLSTPEPMPMSMAPITGENIRPFISRCAVCEAPAMVMAVHSQTIQIPPCPSGWSSLWIGYSFVMHTSAGAEGSGQALASPGSCLEEFRSAPFIECHGRGTCNYYANAYSFWLATIERSEMFKKPTPSTLKAGELRTHVSRCQVCMRRT

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	Source
126	N-linked (GlcNAc...) asparagine	UniProt GlyGen
183		GlyGen
351		GlyGen
517		GlyGen
671		GlyGen
712		GlyGen
753		GlyGen
973		GlyGen
1000		GlyGen
1021		GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
Anchoring fibril formation	Homo sapiens
Assembly of collagen fibrils and other multimeric structures	Homo sapiens
Attachment of bacteria to epithelial cells	Homo sapiens
Collagen biosynthesis and modifying enzymes	Homo sapiens
Collagen chain trimerization	Homo sapiens
Collagen degradation	Homo sapiens
Crosslinking of collagen fibrils	Homo sapiens
ECM proteoglycans	Homo sapiens
Fibronectin matrix formation	Homo sapiens
Integrin cell surface interactions	Homo sapiens

Disease

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0090125	brain small vessel disease 1	Alliance of Genome Resources
DOID:0111547	retinal arterial tortuosity	Alliance of Genome Resources
DOID:13223	uterine fibroid	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements