GlyCosmos Portal

Submissions

collagen type IV alpha 3 chain

Summary

Gene Symbol

COL4A3

Organism

Homo sapiens (human)

External Links

NCBI Gene

1285

KEGG Gene ID

PubChem

1285

Alliance of Genome Resources

HGNC:2204

Annotation

Keyword

3D-structure
Alport syndrome
Alternative splicing
Basement membrane
Cell adhesion
Collagen
Deafness
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Hydroxylation
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q01955	Goodpasture antigen

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
cell adhesion
cell surface receptor signaling pathway	NAS
cell surface receptor signaling pathway	IEA
sensory perception of sound	TAS
negative regulation of cell population proliferation	TAS

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

collagen-activated tyrosine kinase receptor signaling pathway

collagen-activated signaling pathway [inference]

collagen-activated tyrosine kinase receptor signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

endothelial cell apoptotic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

developmental process [inference]

anatomical structure development [inference]

glomerular basement membrane development

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation [inference]

negative regulation of vascular endothelial cell proliferation

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

collagen-activated tyrosine kinase receptor signaling pathway

collagen-activated signaling pathway [inference]

collagen-activated tyrosine kinase receptor signaling pathway

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation [inference]

negative regulation of vascular endothelial cell proliferation

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

negative regulation of endothelial cell proliferation [inference]

negative regulation of vascular endothelial cell proliferation

regulation of vascular endothelial cell proliferation [inference]

negative regulation of vascular endothelial cell proliferation

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation [inference]

negative regulation of vascular endothelial cell proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation [inference]

negative regulation of vascular endothelial cell proliferation

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

Displaying entries **1 - 5** of 14 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular region	IEA
collagen trimer	IEA
collagen type IV trimer	NAS
collagen type IV trimer	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

collagen trimer

network-forming collagen trimer [inference]

collagen type IV trimer

extracellular protein-containing complex [inference]

network-forming collagen trimer [inference]

collagen type IV trimer

cellular anatomical structure [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

basement membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 9 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
integrin binding	TAS
integrin binding	IDA
structural molecule activity	NAS
extracellular matrix structural constituent	IEA
protein binding	IPI

GO Hierarchy

molecular function

structural molecule activity

extracellular matrix structural constituent

extracellular matrix structural constituent conferring tensile strength

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

cell adhesion molecule binding [inference]

integrin binding

protein-containing complex binding [inference]

integrin binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

metalloendopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

metalloendopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

metalloendopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

metalloendopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

collagen

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
Gene Ontology
extracellular matrix organization
extracellular matrix structural constituent conferring tensile strength
extracellular matrix structural constituent

Displaying **all 4** entries
InterPro
C-type lectin fold
Collagen IV, non-collagenous domain superfamily
Collagen IV, non-collagenous
Collagen triple helix repeat

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:783	end stage renal disease	Alliance of Genome Resources
DOID:0111365	benign familial hematuria	Alliance of Genome Resources
DOID:10983	Alport syndrome	Alliance of Genome Resources
DOID:0110033	Alport syndrome 2	Alliance of Genome Resources
DOID:0110032	Alport syndrome 3A	Alliance of Genome Resources