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fibroblast activation protein

Summary

Gene Symbol

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14089

PubChem

14089

Alliance of Genome Resources

MGI:109608

Annotation

Keyword

Alternative splicing
Angiogenesis
Apoptosis
Cell adhesion
Cell junction
Cell membrane
Cell projection
Cleavage on pair of basic residues
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Serine protease
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P97321	Dipeptidyl peptidase FAP Fibroblast activation protein alpha Gelatine degradation protease FAP Integral membrane serine protease Post-proline cleaving enzyme Serine integral membrane protease Surface-expressed protease

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
melanocyte proliferation	IDA	15133496
positive regulation of execution phase of apoptosis	IDA	15133496
melanocyte apoptotic process	IDA	15133496
negative regulation of extracellular matrix organization	ISS
negative regulation of extracellular matrix organization	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

cellular process [inference]

cell adhesion

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

melanocyte apoptotic process

cell population proliferation [inference]

epithelial cell proliferation [inference]

melanocyte proliferation

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

epithelial cell migration [inference]

endothelial cell migration

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of collagen catabolic process

regulation of collagen metabolic process [inference]

regulation of collagen catabolic process

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of cell proliferation involved in contact inhibition

negative regulation of cellular component organization [inference]

negative regulation of extracellular matrix organization

negative regulation of extracellular matrix disassembly

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of cell proliferation involved in contact inhibition

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of cell proliferation involved in contact inhibition

negative regulation of cellular component organization [inference]

negative regulation of extracellular matrix organization

negative regulation of extracellular matrix disassembly

regulation of cellular component organization [inference]

negative regulation of cellular component organization [inference]

negative regulation of extracellular matrix organization

negative regulation of extracellular matrix disassembly

regulation of extracellular matrix organization [inference]

regulation of extracellular matrix disassembly [inference]

negative regulation of extracellular matrix disassembly

negative regulation of extracellular matrix organization

negative regulation of extracellular matrix disassembly

regulation of cell cycle

regulation of execution phase of apoptosis [inference]

positive regulation of execution phase of apoptosis

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GO Term	Evidence Code	PMID
extracellular space	ISO
extracellular space	IEA
plasma membrane	ISS
plasma membrane	ISO
plasma membrane	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

peptidase complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

cell junction [inference]

anchoring junction

leading edge membrane [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

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GO Term	Evidence Code	PMID
protease binding	ISO
protease binding	IEA
endopeptidase activity	ISO
serine-type endopeptidase activity	ISS
serine-type endopeptidase activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

exopeptidase activity [inference]

dipeptidyl-peptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

exopeptidase activity [inference]

dipeptidyl-peptidase activity

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

integrin binding

enzyme binding [inference]

protease binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

cell adhesion molecule binding [inference]

integrin binding

protein-containing complex binding [inference]

integrin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

peptidase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
dipeptidyl-peptidase activity
proteolysis
serine-type peptidase activity

Displaying **all 3** entries
InterPro
Alpha/Beta hydrolase fold
Dipeptidylpeptidase IV, N-terminal domain
Peptidase S9, prolyl oligopeptidase, catalytic domain

Ortholog

Displaying entries **21 - 30** of 79 in total

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Species	Gene ID	Orthologous MAtrix
Monodelphis domestica	100022372	MONDO23185
Equus caballus	100051480	HORSE13781
Ornithorhynchus anatinus	100082270	ORNAN27386
Taeniopygia guttata	100228501	TAEGU28667
Oryctolagus cuniculus	100342791	RABIT11719
Callithrix jacchus	100392684	CALJA37466
Pongo abelii	100437836	PONAB24818
Ailuropoda melanoleuca	100466182	AILME06947
Nomascus leucogenys	100606225	NOMLE12007
Loxodonta africana	100662643	LOXAF19002

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements