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sphingosine-1-phosphate receptor 2

Summary

Gene Symbol

S1pr2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14739

PubChem

14739

Alliance of Genome Resources

MGI:99569

Annotation

Keyword

Cell membrane
G-protein coupled receptor
Glycoprotein
Palmitate
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P52592	Endothelial differentiation G-protein coupled receptor 5 Lysophospholipid receptor B2 Sphingosine 1-phosphate receptor Edg-5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
sphingosine-1-phosphate receptor signaling pathway	ISO
sphingosine-1-phosphate receptor signaling pathway	IMP	23106337
sphingosine-1-phosphate receptor signaling pathway	IBA
G protein-coupled receptor signaling pathway	ISO	29453251
adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

sphingosine-1-phosphate receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

sphingolipid mediated signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

actin filament-based process [inference]

actin cytoskeleton organization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

filopodium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

filopodium assembly

plasma membrane bounded cell projection organization [inference]

plasma membrane bounded cell projection assembly [inference]

filopodium assembly

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of peptidyl-threonine phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of peptidyl-threonine phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of peptidyl-threonine phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of peptidyl-threonine phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of signaling [inference]

regulation of signal transduction [inference]

modulation of excitatory postsynaptic potential [inference]

negative regulation of excitatory postsynaptic potential

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

modulation of excitatory postsynaptic potential [inference]

negative regulation of excitatory postsynaptic potential

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of endothelial cell development [inference]

positive regulation of establishment of endothelial barrier

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of endothelial cell development [inference]

positive regulation of establishment of endothelial barrier

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of excitatory postsynaptic potential

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

modulation of excitatory postsynaptic potential [inference]

negative regulation of excitatory postsynaptic potential

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

regulation of endothelial cell differentiation [inference]

regulation of endothelial cell development [inference]

positive regulation of endothelial cell development [inference]

positive regulation of establishment of endothelial barrier

regulation of establishment of endothelial barrier [inference]

positive regulation of establishment of endothelial barrier

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of endothelial cell development [inference]

positive regulation of establishment of endothelial barrier

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of endothelial cell development [inference]

positive regulation of establishment of endothelial barrier

regulation of endothelial cell development [inference]

positive regulation of endothelial cell development [inference]

positive regulation of establishment of endothelial barrier

regulation of establishment of endothelial barrier [inference]

positive regulation of establishment of endothelial barrier

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of endothelial cell development [inference]

positive regulation of establishment of endothelial barrier

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

regulation of endothelial cell differentiation [inference]

regulation of endothelial cell development [inference]

positive regulation of endothelial cell development [inference]

positive regulation of establishment of endothelial barrier

regulation of establishment of endothelial barrier [inference]

positive regulation of establishment of endothelial barrier

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

sphingosine-1-phosphate receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

sphingolipid mediated signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

modulation of excitatory postsynaptic potential [inference]

negative regulation of excitatory postsynaptic potential

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

modulation of excitatory postsynaptic potential [inference]

negative regulation of excitatory postsynaptic potential

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of peptidyl-threonine phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

regulation of smooth muscle cell proliferation [inference]

negative regulation of smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

regulation of vascular associated smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

regulation of endothelial cell differentiation [inference]

regulation of endothelial cell development [inference]

positive regulation of endothelial cell development [inference]

positive regulation of establishment of endothelial barrier

regulation of establishment of endothelial barrier [inference]

positive regulation of establishment of endothelial barrier

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of endothelial cell development [inference]

positive regulation of establishment of endothelial barrier

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of endothelial cell development [inference]

positive regulation of establishment of endothelial barrier

regulation of endothelial cell development [inference]

positive regulation of endothelial cell development [inference]

positive regulation of establishment of endothelial barrier

regulation of establishment of endothelial barrier [inference]

positive regulation of establishment of endothelial barrier

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of peptidyl-threonine phosphorylation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of endothelial cell development [inference]

positive regulation of establishment of endothelial barrier

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of postsynapse organization [inference]

regulation of postsynapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

modulation of excitatory postsynaptic potential [inference]

negative regulation of excitatory postsynaptic potential

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

regulation of endothelial cell differentiation [inference]

regulation of endothelial cell development [inference]

positive regulation of endothelial cell development [inference]

positive regulation of establishment of endothelial barrier

regulation of establishment of endothelial barrier [inference]

positive regulation of establishment of endothelial barrier

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of postsynaptic membrane potential [inference]

excitatory postsynaptic potential

modulation of excitatory postsynaptic potential [inference]

negative regulation of excitatory postsynaptic potential

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
plasma membrane	ISO	29453251
plasma membrane	IBA
presynapse	IEP	35781853
presynapse	IDA	35781853

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor binding	ISO
G protein-coupled receptor binding	IEA
G protein-coupled receptor activity	ISO
integrin binding	ISO
integrin binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

cell adhesion molecule binding [inference]

integrin binding

protein-containing complex binding [inference]

integrin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled peptide receptor activity

bioactive lipid receptor activity [inference]

sphingosine-1-phosphate receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

sphingosine 1-phosphate receptor

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
sphingosine-1-phosphate receptor activity

Displaying **all 3** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
Sphingosine 1-phosphate receptor

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060060	non-Hodgkin lymphoma	Alliance of Genome Resources
DOID:0110519	autosomal recessive nonsyndromic deafness 68	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 74 in total

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Species	Gene ID	Orthologous MAtrix
Ailuropoda melanoleuca	100469679	AILME10603
Sus scrofa	100511551	PIGXX18462
Anolis carolinensis	100566126	ANOCA14113
Loxodonta africana	100663336	LOXAF11790
Cricetulus griseus	100689183	CRIGR06520
Oreochromis niloticus	100693419	ORENI56683
Cavia porcellus	100714153	CAVPO25379
Sarcophilus harrisii	100934061	SARHA04201
Otolemur garnettii	100963552	OTOGA05172
Pan paniscus	100982485	PANPA19450

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements