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glutamate receptor, metabotropic 8

Summary

Gene Symbol

Grm8

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14823

PubChem

14823

Alliance of Genome Resources

MGI:1351345

Annotation

Keyword

Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Isopeptide bond
Proteomics identification
Reference proteome
Sensory transduction
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q05BD6
P47743
B7ZMR4

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	ISS
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	ISO
G protein-coupled glutamate receptor signaling pathway	IBA
chemical synaptic transmission	ISO

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, glutamatergic

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

G protein-coupled glutamate receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

G protein-coupled glutamate receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

response to abiotic stimulus [inference]

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of stimulus involved in sensory perception of pain [inference]

detection of mechanical stimulus involved in sensory perception of pain

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, glutamatergic

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of neurotransmitter secretion

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

G protein-coupled glutamate receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

G protein-coupled glutamate receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of secretion by cell [inference]

regulation of neurotransmitter secretion

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
plasma membrane	ISO
plasma membrane	TAS	16045496
plasma membrane	IBA
presynaptic membrane	ISO
neuronal cell body	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

cell junction [inference]

synapse

cell body [inference]

neuronal cell body

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
group III metabotropic glutamate receptor activity	ISO
group III metabotropic glutamate receptor activity	IDA	7722646
group III metabotropic glutamate receptor activity	IBA
G protein-coupled receptor activity	ISS
G protein-coupled receptor activity	ISO

GO Hierarchy

molecular function

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled glutamate receptor activity [inference]

adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [inference]

group III metabotropic glutamate receptor activity

glutamate receptor activity

G protein-coupled glutamate receptor activity [inference]

adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [inference]

group III metabotropic glutamate receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

metabotropic glutamate receptor

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
regulation of synaptic transmission, glutamatergic

Displaying **all 6** entries
InterPro
GPCR family 3, C-terminal
GPCR, family 3, nine cysteines domain superfamily
GPCR, family 3, nine cysteines domain
GPCR, family 3
Periplasmic binding protein-like I
Receptor, ligand binding region

Ortholog

Displaying entries **11 - 20** of 99 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	24419	WB:WBGene00003232
Caenorhabditis elegans	43838	WB:WBGene00003232
Rattus norvegicus	60590	ZFIN:ZDB-GENE-110421-3	RATNO29812
Caenorhabditis elegans	108068	WB:WBGene00003232
Caenorhabditis elegans	108069	WB:WBGene00003232
Homo sapiens	191707	HGNC:4600
Caenorhabditis elegans	268934	WB:WBGene00003232
Pan troglodytes	472502		PANTR41312
Canis lupus familiaris	482270		CANLF03600
Bos taurus	538360		BOVIN28363