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hyperpolarization-activated, cyclic nucleotide-gated K+ 2

Summary

Gene Symbol

Hcn2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

15166

PubChem

15166

Alliance of Genome Resources

MGI:1298210

Annotation

Keyword

3D-structure
Ammonia transport
Cell membrane
Glycoprotein
Ligand-gated ion channel
Methylation
Palmitate
Phosphoprotein
Potassium channel
Reference proteome
Sodium channel
Transmembrane helix
Voltage-gated channel
cAMP-binding

Proteins

Displaying 1 entry
UniProt	Protein Name
O88703	Brain cyclic nucleotide-gated channel 2 Hyperpolarization-activated cation channel 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
regulation of membrane depolarization	IBA
sodium ion transmembrane transport	ISO
sodium ion transmembrane transport	IBA
regulation of membrane potential	ISO
regulation of membrane potential	IDA	15564593

GO Hierarchy

biological process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to oxygen-containing compound [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

ammonium transmembrane transport

inorganic cation import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

response to stimulus [inference]

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

response to cGMP [inference]

cellular response to cGMP

cellular response to organonitrogen compound [inference]

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

response to cGMP [inference]

cellular response to cGMP

cellular response to organic cyclic compound [inference]

response to organophosphorus [inference]

response to cAMP [inference]

cellular response to cAMP

response to cGMP [inference]

cellular response to cGMP

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to oxygen-containing compound [inference]

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

response to cGMP [inference]

cellular response to cGMP

cellular response to organonitrogen compound [inference]

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

response to oxygen-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

response to cGMP [inference]

cellular response to cGMP

cellular response to oxygen-containing compound [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to oxygen-containing compound [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

sodium ion transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

ammonium transmembrane transport

inorganic cation import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

nitrogen compound transport [inference]

ammonium transmembrane transport

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of membrane depolarization

regulation of biological quality [inference]

regulation of membrane potential

regulation of membrane depolarization

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
plasma membrane	ISS
plasma membrane	ISO
membrane	IDA	30886335
axon	ISO
axon	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated potassium channel complex [inference]

HCN channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex [inference]

HCN channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex [inference]

HCN channel complex

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane [inference]

dendrite membrane

leading edge membrane [inference]

neuron projection membrane [inference]

dendrite membrane

somatodendritic compartment

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendritic shaft

cell body [inference]

neuronal cell body

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
intracellular cAMP-activated cation channel activity	ISS
intracellular cAMP-activated cation channel activity	ISO
voltage-gated sodium channel activity	ISO
voltage-gated sodium channel activity	IEA
voltage-gated potassium channel activity	ISS

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

ligand-gated monoatomic cation channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellular cAMP-activated cation channel activity

ligand-gated monoatomic ion channel activity [inference]

intracellular ligand-gated monoatomic ion channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellular cAMP-activated cation channel activity

cyclic nucleotide-activated monoatomic ion channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellular cAMP-activated cation channel activity

ligand-gated monoatomic cation channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellular cAMP-activated cation channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

ligand-gated monoatomic cation channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellular cAMP-activated cation channel activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

sodium channel activity [inference]

voltage-gated sodium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

ligand-gated monoatomic cation channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellular cAMP-activated cation channel activity

ligand-gated monoatomic ion channel activity [inference]

intracellular ligand-gated monoatomic ion channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellular cAMP-activated cation channel activity

cyclic nucleotide-activated monoatomic ion channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellular cAMP-activated cation channel activity

ligand-gated monoatomic cation channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellular cAMP-activated cation channel activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

intracellular ligand-gated monoatomic ion channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellular cAMP-activated cation channel activity

cyclic nucleotide-activated monoatomic ion channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellular cAMP-activated cation channel activity

ligand-gated monoatomic cation channel activity [inference]

intracellular cyclic nucleotide-activated monoatomic cation channel activity [inference]

intracellular cAMP-activated cation channel activity

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

binding [inference]

protein binding

protein domain specific binding [inference]

PDZ domain binding

identical protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

cyclic nucleotide binding [inference]

cAMP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

ion binding [inference]

anion binding [inference]

cAMP binding

protein-containing complex binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

cyclic nucleotide binding [inference]

cAMP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

molecular adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cyclic nucleotide-gated cation channel

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
monoatomic ion channel activity
monoatomic ion transport

Displaying **all 4** entries
InterPro
Cyclic nucleotide-binding domain superfamily
Cyclic nucleotide-binding domain
Ion transport domain
RmlC-like jelly roll fold

Ortholog

Displaying entries **1 - 10** of 27 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	610	ZFIN:ZDB-GENE-030131-8228	HUMAN39200
Drosophila melanogaster	10021	FB:FBgn0263397
Drosophila melanogaster	15165	FB:FBgn0263397
Danio rerio	15166	ZFIN:ZDB-GENE-030131-8228
Drosophila melanogaster	15168	FB:FBgn0263397
Drosophila melanogaster	57657	FB:FBgn0263397
Drosophila melanogaster	59266	FB:FBgn0263397
Drosophila melanogaster	84390	FB:FBgn0263397
Rattus norvegicus	114244	ZFIN:ZDB-GENE-030131-8228	RATNO39549
Drosophila melanogaster	114245	FB:FBgn0263397

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