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Guidelines

MIRAGE

heat shock protein family A (Hsp70) member 9

Summary

Gene Symbol

Hspa9

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

15526

KEGG Gene ID

PubChem

15526

Alliance of Genome Resources

MGI:96245

Annotation

Keyword

ATP-binding
Acetylation
Chaperone
Cytoplasm
Direct protein sequencing
Hydrolase
Methylation
Mitochondrion
Nucleus
Phosphoprotein
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
P38647	75 kDa glucose-regulated protein Heat shock 70 kDa protein 9 Mortalin Peptide-binding protein 74 p66 MOT

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	PMID
protein folding	IEA
protein export from nucleus	IDA
response to toxic substance	IEA
iron-sulfur cluster assembly	ISO
iron-sulfur cluster assembly	IMP

GO Hierarchy

biological process

cellular process [inference]

protein folding

protein refolding

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation [inference]

protein autophosphorylation

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

intercellular transport [inference]

calcium import into the mitochondrion

nuclear export [inference]

protein export from nucleus

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein export from nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

protein export from nucleus

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

metallo-sulfur cluster assembly [inference]

iron-sulfur cluster assembly

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to thyroid hormone [inference]

response to thyroxine

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to folic acid

response to chemical [inference]

response to acid chemical [inference]

response to amino acid [inference]

response to thyroxine

response to nutrient [inference]

response to vitamin [inference]

response to folic acid

response to toxic substance

response to hormone [inference]

response to thyroid hormone [inference]

response to thyroxine

response to peptide [inference]

response to cytokine [inference]

response to interleukin-1 [inference]

cellular response to interleukin-1

cellular response to cytokine stimulus [inference]

cellular response to interleukin-1

response to nitrogen compound [inference]

response to folic acid

response to L-phenylalanine derivative [inference]

response to thyroxine

response to oxygen-containing compound [inference]

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein export from nucleus

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

intercellular transport [inference]

calcium import into the mitochondrion

nuclear export [inference]

protein export from nucleus

protein transport [inference]

intracellular protein transport [inference]

protein export from nucleus

intracellular transport [inference]

intracellular protein transport [inference]

protein export from nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

protein export from nucleus

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein export from nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein export from nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

protein export from nucleus

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein export from nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

protein export from nucleus

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of hemopoiesis

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

regulation of erythrocyte differentiation

negative regulation of erythrocyte differentiation

negative regulation of hemopoiesis

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of hemopoiesis

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of multicellular organismal process [inference]

negative regulation of hemopoiesis

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

regulation of erythrocyte differentiation

negative regulation of erythrocyte differentiation

negative regulation of hemopoiesis

regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of hematopoietic stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of stem cell differentiation [inference]

regulation of hematopoietic stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

regulation of erythrocyte differentiation

negative regulation of erythrocyte differentiation

negative regulation of hemopoiesis

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

regulation of erythrocyte differentiation

negative regulation of erythrocyte differentiation

negative regulation of hemopoiesis

regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of hematopoietic stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of stem cell differentiation [inference]

regulation of hematopoietic stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of hemopoiesis

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of erythrocyte differentiation

regulation of erythrocyte differentiation

negative regulation of erythrocyte differentiation

negative regulation of hemopoiesis

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
nucleolus	IEA
cytoplasm	ISO
cytoplasm	EXP
cytoplasm	TAS
cytoplasm	IBA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm

nucleoid [inference]

mitochondrial nucleoid

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

myelin sheath

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

membraneless organelle [inference]

intracellular membraneless organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular membraneless organelle [inference]

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
protein binding	IPI
ATP binding	IEA
ATP hydrolysis activity	ISS
ATP hydrolysis activity	ISO
ATP hydrolysis activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding

growth factor binding [inference]

fibroblast growth factor binding

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein folding chaperone

ATP-dependent protein folding chaperone

ATP-dependent activity [inference]

ATP-dependent protein folding chaperone

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

heat shock

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
Gene Ontology
ATP binding
ATP-dependent protein folding chaperone
nucleotide binding

Displaying **all 5** entries
InterPro
ATPase, nucleotide binding domain
Heat shock protein 70 family
Heat shock protein 70, conserved site
Heat shock protein 70kD, C-terminal domain superfamily
Heat shock protein 70kD, peptide-binding domain superfamily

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Last updated: April 6, 2026